氧化低密度脂蛋白在动脉粥样硬化性心血管疾病诊断中的作用  

Role of oxidized low density lipoprotein in the diagnosis of atherosclerotic cardiovascular disease

作　　者：杨鑫 胡炎伟 Yang Xin;Hu Yanwei(Department of Clinical Laboratory,Guangzhou Women and Childrens Medical Center,Guangzhou 510000,China)

机构地区：[1]广州市妇女儿童医疗中心检验科,广州510000

出　　处：《中华检验医学杂志》2021年第7期563-568,共6页Chinese Journal of Laboratory Medicine

基　　金：国家自然基金项目(82072335,81871701);广东省自然科学基金杰出青年项目(2020B1515020013)。

摘　　要：氧化低密度脂蛋白(oxLDL)作为致动脉粥样硬化(AS)的关键分子,在损伤血管内皮细胞,促进单核细胞黏附,诱导泡沫细胞和血栓形成等方面发挥着至关重要的作用。随着研究的深入,发现oxLDL能够作为循环生物标志物,用于AS及其相关疾病的诊断。该文阐述oxLDL在AS发生发展中的作用机制及其作为AS相关疾病的诊断标志物的研究进展。As a critical factor of atherosclerosis(AS),oxidized low-density lipoprotein(oxLDL)plays a crucial role in damaging vascular endothelial cells,promoting monocyte adhesion,inducing formation of foam cells and thrombosis.Many scholars have found that oxLDL could be used as a circulating biomarker for atherosclerotic cardiovascular disease.In this manuscript,research progress on the mechanism of oxLDL in the initiation and development of atherosclerosis,as well as using oxLDL as a diagnostic biomarker of atherosclerosis related diseases were systemically reviewed.

关 键 词：动脉粥样硬化 氧化低密度脂蛋白 心血管疾病 生物学标记 

分 类 号：R54[医药卫生—心血管疾病]