核苷(酸)类药物对慢性乙型肝炎患者血清HBV DNA和RNA定量检测的影响  

The influence of nucleos(t)ide analogs on the accuracy of HBV DNA and RNA quantitative detection

作　　者：刘明琛 杨兴雯 彭思雯 邹军 鲁凤民[1,2] Liu Mingchen;Yang Xingwen;Peng Siwen;Zou Jun;Lu Fengmin(Department of Microbiology&Infectious Disease Center,School of Basic Medical Sciences,Peking University Health Science Center,Beijing 100191,China;Hepatology Institute,Peking University People’s Hospital,Beijing 100044,China)

机构地区：[1]北京大学基础医学院病原生物学系暨感染病中心,100191 [2]北京大学人民医院肝病研究所,100044

出　　处：《中华实验和临床病毒学杂志》2021年第3期305-311,共7页Chinese Journal of Experimental and Clinical Virology

基　　金：国家科技重大专项(2017ZX10302201);国家自然科学基金(81672013)。

摘　　要：核苷(酸)类药物是目前临床上最主要的慢性乙型肝炎抗病毒药物之一,可以有效抑制HBV复制。血清HBV DNA可以反映HBV复制水平,是目前临床上最常用的病毒学检测指标。血清HBV RNA作为新兴的病毒学指标在监测肝细胞内cccDNA的活性以及评估停药风险方面具有重要意义。本文关注了核苷(酸)类药物抗病毒治疗对血清中病毒核酸性质和对定量结果的影响,总结了目前病毒核酸定量的常用方法,评价了血清HBV DNA和RNA联检对慢性乙型肝炎治疗的重要指导意义。Nucleos(t)ide analogs(NAs)are one of the two main antiviral agents used in clinical practice,which can effectively inhibit HBV replication.Serum HBV DNA is one of the most commonly used virologic markers used to assess HBV replication level.In recent years,more and more studies have suggested that serum HBV RNA is one of the ideal surrogates of cccDNA activity.This article summarized the influence of serum viral nucleic acid properties and quantitative result during treatment with NAs,as well as current method of viral nucleic acid quantification.And finally,it evaluates the significance of HBV DNA and RNA joint testing for CHB treatment.

关 键 词：慢性乙型肝炎 核苷(酸)类药物 核酸定量 

分 类 号：R512.62[医药卫生—内科学]