有机化学实验创新:3-[(2-羟基-1-萘基)偶氮基]苯甲醛的合成  

Innovative Organic Chemistry Experiment:Synthesis of 3-[(2-hydroxy-1-naphthalene)azo]benzaldehyde

作　　者：孙雨辰 侯昭升[1] 张礼 高雅 SUN Yu-Chen;HOU Zhao-Sheng;ZHANG Li;GAO Ya(College of Chemistry,Chemical Engineering and Material Science,Shandong Normal University,Ji’nan 250100,China)

机构地区：[1]山东师范大学化学化工与材料科学学院,山东济南250100

出　　处：《化学教育（中英文）》2021年第14期55-58,共4页Chinese Journal of Chemical Education

基　　金：大学生创新创业项目(202010445514)。

摘　　要：针对目前大学基础有机化学实验教学中的实验缺乏连贯性和系统性等问题,首次将硝基还原和芳胺重氮化偶联2个反应结合起来。主要以间硝基苯甲醛为原料,不进行中间体纯化,连续通过硝基还原、重氮化偶联反应直接制备偶氮染料——3-[(2-羟基-1-萘基)偶氮基]苯甲醛。改进后的实验将2个原本孤立的实验联系在一起,让本科生在掌握实验原理和基础实验操作的基础上,体会到有机化学基础实验之间的内在联系。同时该创新实验可以进一步拓展成综合实验,更有利于学生系统地理解和掌握化学实验技术,并锻炼主动探索精神和综合实践能力。Because of the lack of consistency and systematicness in the basic organic chemistry experiment,an innovative experiment combining the reactions of nitroreduction and diazotization-coupling was carried out in this paper.Adopting m-nitrobenzaldehyde as raw material,the azo dye of 3-[(2-hydroxy-1-naphthalene)azo]benzaldehyde was synthesized by reduction,diazotization and coupling reaction without purification of intermediates.In the innovative experiment,two isolated experiments were combined systematically,which could make the students realize the internal relationship between basic chemical experiments.In addition,the innovative experiment could also be further extended to comprehensive experiment,which was more conducive for students to have systematic understanding and mastering the experiment technology,and to exercise their initiative exploration spirit and comprehensive practice ability.

关 键 词：有机实验创新 硝基还原 重氮化偶联 

分 类 号：O625.41-4[理学—有机化学] G642.423[理学—化学]