Preparation and Characterization of Bimodal Magnetofluorescent Nanoprobes for Biomedical Application  

作　　者：LEI Jie-Mei XU Xiao-Liang LIU Ling YIN Nai-Qiang ZHU Li-Xin 雷洁梅;许小亮;刘玲;尹乃强;朱立新(Department of Physics,University of Science and Technology of China,Hefei 230026;Center Laboratory,First Affiliated Hospital,Anhui Medical University,Hefei 230022)

机构地区：[1]Department of Physics,University of Science and Technology of China,Hefei 230026 [2]Center Laboratory,First Affiliated Hospital,Anhui Medical University,Hefei 230022

出　　处：《Chinese Physics Letters》2012年第9期188-192,共5页中国物理快报（英文版）

基　　金：Supported by the National Natural Science Foundation of China under Grant Nos 50872129 and 81172082.

摘　　要：Magnetic-fluorescent bifunctional Fe_(3)O_(4)/SiO_(2)-CdTeS nanocomposites are synthesized.Fe_(3)O_(4) superparamagnetic nanoparticles are firstly prepared through the thermal decomposition of Fe oleate precursors and coated with a mesoporous silica shell using the Stöber method,and the silica surface is then modified with positively charged amino groups by adding 3-aminopropyltrimethoxysilane.Finally,negatively charged CdTeS quantum dots are linked and assembled onto the positively charged surface of Fe_(3)O_(4)/SiO_(2) through electrostatic interactions.X-ray diffraction,transmission electron microscopy,photoluminescence spectroscopy,and magnetometry are applied to characterize the nanocomposites.The results show that the bifunctional nanocomposites combine the optical properties of near-infrared CdTeS quantum dots with the superparamagnetic properties of Fe_(3)O_(4) perfectly,expressing the potential application as a biocompatible magnetofuorescent nanoprobe for in vivo labelling.

关 键 词：MODAL SILICA adding 

分 类 号：R52[医药卫生—内科学]