维生素D在镉毒性效应中的作用  

Research progress on effect of vitamin D in cadmium toxicity

作　　者：李艳萍 闵珍[2] 孙道远[2] 丑欣 LI Yan-ping;MIN Zhen;SUN Dao-yuan;CHOU Xin(The Third People's Hospital of Honghe Prefecture,Gejiu 661000,China)

机构地区：[1]云南红河州第三人民医院,云南个旧661000 [2]同济大学附属上海市肺科医院中毒科理化实验室

出　　处：《中国工业医学杂志》2021年第3期222-225,共4页Chinese Journal of Industrial Medicine

基　　金：上海市科学技术委员会国内合作项目(20015800300);上海市青年科技英才扬帆计划资助(20YF1441200)。

摘　　要：镉是自然界天然存在的重金属元素。我国部分地区土壤存在不同程度的镉污染,农作物和饮水中也存在不同程度的镉残留。镉可引起多器官损伤,尤其以对肝脏、肾脏和骨骼损害最为明显。镉引起的"痛痛病"与机体本身的营养状态有关,尤其是维生素D缺乏。维生素D是一种脂溶性维生素,其代谢异常及继发的钙磷代谢障碍可导致骨质疏松、骨软化等疾病的发生。肾脏、肝脏和骨骼是维生素D的代谢及作用的主要场所。本文拟就镉对维生素D代谢途径的干扰作用及缺乏或补充维生素D对镉毒性效应的影响进行简要综述,以期为探究维生素D作为预防或缓解镉引起的肝脏、肾脏、骨骼和肠道毒性的可行性提供一些理论基础。Cadmium is a naturally produced heavy metal element, human activities and natural movement can also produce cadmium, resulting in cadmium pollution.In some areas of China, there were different degrees of cadmium pollution in soil, as well as some cadmium residue in crops and drinking water were found.Cadmium can cause multiple organs damage, especially liver, kidney and bone.Some scholars believe that the ‘Itai-itai disease’ caused by cadmium is also related to the nutritional status, especially vitamin D deficiency.Vitamin D is a fat-soluble vitamin, abnormal vitamin D metabolism and secondary calcium and phosphorus metabolic disorders can cause osteoporosis and osteomalacia, etc.Kidney, liver and bone are also the main sites of metabolism and action of vitamin D.This article would make a brief review on the interference role of cadmium in vitamin D metabolic pathways and the effect of Vitamin D deficiency or supplement on the toxic effects of cadmium, thereby, providing some theoretic basis for exploring the feasibility of vitamin D to prevent or alleviate liver, kidney, bone, and intestinal toxicity caused by cadmium.

关 键 词：镉 维生素D 肝肾毒性 骨骼毒性 

分 类 号：R994.3[医药卫生—毒理学]