金匮温经汤对肾虚血瘀型免疫性卵巢早衰患者性激素水平及临床证候积分的影响  

Effect of Jinkui Wenjing Tang on Levels of Sex Hormones and Clinical Syndrome Score in Patients with Autoimmune Premature Ovarian Failure of Kidney Deficiency and Blood Stasis Type

作　　者：汤传梅[1] 沙丹 TANG Chuanmei;SHA Dan

机构地区：[1]南阳医学高等专科学校第二附属医院妇科,河南南阳473000

出　　处：《新中医》2021年第14期1-5,共5页New Chinese Medicine

摘　　要：目的:探讨金匮温经汤对肾虚血瘀型免疫性卵巢早衰患者性激素水平及临床证候积分的影响。方法:纳入124例肾虚血瘀型免疫性卵巢早衰患者为研究对象,按照随机数字表法分为对照组和研究组,各62例,对照组采用雌二醇环丙孕酮片治疗,研究组在对照组基础上加服金匮温经汤,连续治疗3个月,采用化学发光法检测患者卵泡刺激素(FSH)、雌二醇(E_(2))、黄体生成激素(LH)和抗缪勒管激素(AMH)水平,记录患者肝肾功能、大便常规、尿常规、血常规检查结果,按照中医症状评分标准评定患者临床证候积分,治疗过程中记录患者月经周期和月经量,并记录治疗效果。结果:治疗前,2组AMH、E_(2)、LH、FSH水平比较,差异无统计学意义(P>0.05)。治疗后,2组FSH水平均下降,且研究组FSH水平低于对照组,E_(2)水平均升高,且研究组E_(2)水平高于对照组,差异有统计学意义(P<0.05);治疗后,研究组LH水平下降,且低于对照组,AMH水平升高,且高于对照组,差异有统计学意义(P<0.05)。对照组治疗前后LH、AMH水平比较,差异无统计学意义(P>0.05)。治疗前,2组临床证候积分、月经周期及月经量比较,差异无统计学意义(P>0.05),经过治疗,2组月经周期均下降,且研究组短于对照组,月经量均增加,且研究组多于对照组,差异有统计学意义(P<0.05)。治疗后研究组临床证候积分低于治疗前,且低于对照组,差异有统计学意义(P<0.05)。治疗前后对照组临床证候积分比较,差异无统计学意义(P>0.05)。研究组总有效率93.55%,高于对照组的77.42%,差异有统计学意义(P<0.05)。2组无不良反应发生。结论:金匮温经汤能够明显改善肾虚血瘀型免疫性卵巢早衰患者性激素水平,降低临床证候积分,提高治疗效果。Objective:To discuss the effect of Jinkui Wenjing tang on levels of sex hormones and clinical syndrome score in patients with autoimmune premature ovarian failure of kidney deficiency and blood stasis type.Methods:A total of 124 cases of patients with autoimmune premature ovarian failure of kidney deficiency and blood stasis type were enrolled as the study objects,and were divided into the control group and the study group according to the random number table method,62 cases in each group.The control group was given estradiol cyproterone tablets,and the study group was additionally given the oral administration of Jinkui Wenjing tang based on the treatment of the control group.Both groups were continuously treated for three months.Chemiluminescent method was used to detect levels of follicle-stimulating hormone(FSH),estradiol(E_(2)),luteinizing hormone(LH),and anti-Mullerian hormone(AMH).The examination results of the liver function,the kidney function,stool routine,urine routine,and blood routine were recorded.The clinical syndrome score was evaluated according to standard of Chinese medicine symptom scores.During treatment,menstrual cycle,menstrual volume,and the curative effect were recorded.Results:Before treatment,when compared levels of AMH,E_(2),LH,and FSH between the two groups,there was no significance being found in the difference(P>0.05).After treatment,levels of FSH in the two groups were decreased,and the level in the study group was lower than that in the control group;levels of E_(2) in the two groups were increased,and the level in the study group was higher than that in the control group;the difference was significant(P<0.05).After treatment,the level of LH in the study group was decreased and lower than that in the control group;the level of AMH in the study group was increased and higher than that in the control group;the difference was significant(P<0.05).In the control group,when compared levels of LH and AMH before treatment with those after treatment,there was no significance being found in

关 键 词：免疫性卵巢早衰 性激素水平 金匮温经汤 肾虚血瘀型 临床证候积分 

分 类 号：R711.75[医药卫生—妇产科学]