小青龙汤加味治疗变应性鼻炎患儿临床研究  

Clinical Study on Modified Xiaoqinglong Tang for Children with Rhinallergosis

作　　者：孙秉奎 张可[1] 魏艳艳[1] SUN Bingkui;ZHANG Ke;WEI Yanyan

机构地区：[1]郑州大学附属儿童医院耳鼻咽喉科,河南郑州450000

出　　处：《新中医》2021年第14期14-17,共4页New Chinese Medicine

摘　　要：目的:观察小青龙汤加味治疗变应性鼻炎患儿的临床疗效及对患儿Th1、Th2免疫平衡的影响。方法:选择69例变应性鼻炎患儿进行回顾性分析,根据患儿不同治疗方案将纳入研究的病例资料分为观察组和对照组。对照组口服氯雷他定片治疗,观察组在对照组基础上服用小青龙汤加味,14 d为1个疗程。对比2组治疗2个疗程后的疗效;对比2组治疗前后鼻分泌物嗜酸性粒细胞计数(EOS)、血总免疫球蛋白E(tIgE)含量及血清Th1、Th2细胞相关因子含量。结果:与对照组比较,观察组显效率较高(P<0.05),无效率较低(P<0.05)。与同组治疗前比较,2组治疗后EOS、tIgE含量及血清白细胞介素-4(IL-4)、白细胞介素-8(IL-8)含量均降低(P<0.05),血清白细胞介素-2(IL-2)、干扰素-γ(INF-γ)含量均升高(P<0.05)。与对照组治疗后比较,观察组治疗后EOS、tIgE含量及血清IL-4、IL-8含量均较低(P<0.05),血清IL-2、INF-γ含量均较高(P<0.05)。结论:小青龙汤加味可通过调节变应性鼻炎患儿tIgE含量以纠正Th1/Th2细胞平衡偏移,促进患儿康复。Objective:To observe the clinical effect of modified Xiaoqinglong tang for children with rhinallergosis and its effect on the immune balance of Th1 and Th2.Methods:A total of 69 cases of children with rhinallergosis were retrospectively analyzed,and the data of the included cases were divided into the observation group and the control group according to different treatment schemes.The control group was given the oral administration of loratadine tablets,and the observation group was additionally treated with modified Xiaoqinglong tang based on the treatment of the control group,14 days being a course of treatment.The curative effect after two courses of treatment in the two groups was compared;the counting of eosinophilic leucocytes(EOS)in nasal secretion,the contents of total immunoglobulin E(tIgE)in blood and the contents of Th1 and Th2 cell-related factors in serum before and after treatment in the two groups were compared.Results:Compared with those in the control group,the effective rate in the observation group was higher(P<0.05),and the ineffective rate was lower(P<0.05).After treatment,the contents of EOS,tIgE and interleukin-4(IL-4)and interleukin-8(IL-8)in serum in the two groups were decreased when compared with those before treatment(P<0.05),and the contents of interleukin-2(IL-2)and interferon-γ(INF-γ)in serum were increased(P<0.05).After treatment,the contents of EOS,tIgE and IL-4 and IL-8 in serum in the observation group were lower than those in the control group(P<0.05),and the contents of IL-2 and INF-γin serum were higher(P<0.05).Conclusion:Modified Xiaoqinglong tang can correct the balance deviation of Th1/Th2 cells by regulating the tIgE contents in children with rhinallergosis and promote their recovery.

关 键 词：变应性鼻炎 小青龙汤 嗜酸性粒细胞 TH1/TH2 

分 类 号：R276.1[医药卫生—中医五官科学]