血浆网膜素-1及超敏C反应蛋白水平与冠心病发生与发展的关系  

Associations of Omentin-1 and Hypersensitive C-Reactive Protein Levels in Plasma with the Occurrence and Development of Coronary Heart Disease

作　　者：陆士娟[1] 钟江华[1] 吴淼[1] 李强[1] 黄康[1] 陈智伟 Lu Shijuan;Zhong Jianghua;Wu Miao;Li Qiang;Huang Kang;Chen Zhiwei(Department of Cardiology,Haikou People's Hospital,Haikou Hainan 570000,China;Department of Cardiology,Loudi Central Hospital,Loudi Hunan 417000,China)

机构地区：[1]海口市人民医院心血管内科,海南海口570000 [2]娄底市中心医院心血管内科,湖南娄底417000

出　　处：《医疗装备》2021年第15期3-5,共3页Medical Equipment

基　　金：海南省医药卫生科研项目(1401000320A2014)。

摘　　要：目的分析冠心病患者血浆网膜素-1(Omentin-1)、超敏C反应蛋白(hs-CRP)水平变化,研究两者与冠心病发生、发展的关系。方法选取2016年12月至2018年12月于海口市人民医院心血管内科行冠状动脉造影的209例患者,根据造影结果分为冠心病组(126例)与正常对照组(83例),检测两组血浆Omentin-1、hs-CRP水平,并采用Gensini评分评估冠心病组冠状动脉病变严重程度,分析Gensini评分与血浆Omentin-1、hs-CRP水平的相关性。结果冠心病组Gensini评分为(42.30±6.69)分;冠心病组血浆Omentin-1水平低于正常对照组,hs-CRP水平高于正常对照组,差异均有统计学意义(P<0.05);Pearson相关分析显示,冠心病组Gensini评分与血浆Omentin-1水平成负相关(r=-0.638,P<0.05),与血浆hs-CRP水平成正相关(r=0.693,P<0.05)。结论血浆Omentin-1水平的降低及hs-CRP水平的升高与冠心病的发生与发展存在一定关联,可作为评估冠状动脉病变严重程度的评价指标。Objective The changes of Omentin-1 and hypersensitive C-reactive protein(hs-CRP)in plasma of patients with coronary heart disease(CHD)were analyzed,and the associations between them and the occurrence and development of CHD was investigated.Methods A total of 209 patients who underwent coronary angiography examination from December 2016 to December 2018 in the Department of Cardiology of Haikou People's Hospital were selected as the subjects in this study.According to the results of coronary angiography,they were divided into a CHD group(126 cases)and a normal control group(83 cases).The Omentin-1 and hs-CRP levels in patients'plasma were detected and the severity degree of coronary artery lesion of the CHD group was accessed by Gensini score,and then the associations between Gensini score and Omentin-1,hs-CRP levels in plasma were analyzed.Results The Gensini scores of the CHD group were(42.30±6.69);The level of Omentin-1 in plasma of the CHD group was lower than that of the normal control group,while the level of hs-CRP was higher than that of the normal control group,and the differences were both statistically significant(P<0.05);The Pearson correlation analysis showed that Gensini scores of the CHD group had negative correlation with Omentin-1 in plasma(r=-0.638,P<0.05)and positive correlation with hs-CRP in plasma(r=0.693,P<0.05).Conclusion The decrease of Omentin-1 level and elevation of hs-CRP level in plasma are related to the occurrence and development of CHD,and so they can serve as the indexes to assess the severity degree of coronary artery lesion.

关 键 词：冠心病 网膜素-1 超敏C反应蛋白 

分 类 号：R541.4[医药卫生—心血管疾病]