天然膜仿生递药系统在肿瘤治疗中的应用进展  

Research progress in cell biomimetic drug delivery systems for tumor therapy

作　　者：田然 王智勇 牛瑞芳 Ran Tian;Zhiyong Wang;Ruifang Niu(Department of Public Laboratory,Tianjin Medical University Cancer Institute and Hospital,National Clinical Research Center for Cancer,Tianjin Key Laboratory of Cancer Prevention and Therapy,Tianjin’s Clinical Research Center for Cancer,300060,China)

机构地区：[1]天津医科大学肿瘤医院公共实验室,国家肿瘤临床医学研究中心,天津市“肿瘤防治”重点实验室,天津市恶性肿瘤临床医学研究中心,天津市300060

出　　处：《中国肿瘤临床》2021年第13期690-694,共5页Chinese Journal of Clinical Oncology

基　　金：国家自然科学基金项目(编号:81903092);天津市卫生健康科研项目(编号:KJ20174)资助。

摘　　要：药物递送系统在肿瘤治疗中具有广阔的应用前景,但作为外源物质,易被机体免疫系统所识别与清除,临床应用受到限制。近年来,受自然界生物系统启发,随着仿生技术发展,天然膜仿生递药系统成为研究热点。天然膜仿生药物递送系统主要是利用机体内源性细胞膜对功能性纳米药物载体进行修饰,有效地将细胞膜的天然属性与纳米载体的优势相结合,具有免疫原性低、血液循环时间长的特点。本文将根据天然膜的来源不同,对仿生药物递送系统在肿瘤治疗中的研究进展并对其未来的发展进行综述。Nanomedicine holds promising potential in the tumor therapeutic field,although the characteristics of nanomaterials that are easily recognized and eliminated by the immune system considerably limit clinical applications.Inspired by natural biological systems,biomimetic drug delivery systems have attracted growing attention in recent years.Biomimetic nanoparticles assembled by natural biomaterials such as cell membranes and various synthetic nanoparticles might be promising therapeutic tools for anti-tumor drug delivery.In line with cell membrane properties,biomimetic nanoparticles display prolonged circulation and good biocompatibility.According to the different sources of natural membranes,this study reviews the research progress in biomimetic drug delivery systems in tumor treatment and the prospects for its future development.

关 键 词：细胞膜 仿生递药系统 肿瘤治疗 

分 类 号：R943[医药卫生—药剂学]