替格瑞洛在急性心肌梗死经皮冠状动脉介入治疗术后抗血小板治疗中的应用效果  

Application effect of Ticagrelor on antiplatelet therapy after percutaneous coronary intervention in acute myocardial infarction

作　　者：王艳玲 WANG Yan-ling(Department of Cardiovascular Medicine,Xiangzhou District People′s Hospital of Xiangyang City,Hubei Province,Xiangyang 441100,China)

机构地区：[1]湖北省襄阳市襄州区人民医院心血管内科,湖北襄阳441100

出　　处：《中国当代医药》2021年第22期79-82,共4页China Modern Medicine

摘　　要：目的探讨替格瑞洛在急性心肌梗死经皮冠状动脉介入治疗(PCI)术后抗血小板治疗中的效果。方法选取2019年1月—2020年6月襄阳市襄州区人民医院收治的100例急性心肌梗死患者为研究对象,按照随机数字表法分为观察组和对照组,每组各50例。观察组PCI术前术后服用阿司匹林+替格瑞洛,对照组PCI术前术后服用阿司匹林+氯吡格雷。比较两组患者的血小板聚集率、肝功能、不良反应发生情况及不良心血管事件总发生率。结果术前两组患者的血小板聚集率比较,差异无统计学意义(P>0.05);观察组术后2、24 h、术后7 d的血小板聚集率低于对照组,差异有统计学意义(P<0.05)。术前两组患者的肝功能比较,差异无统计学意义(P>0.05);观察组术后7 d的谷草转氨酶、血肌酐水平高于术前,且高于对照组,差异有统计学意义(P<0.05)。观察组不良反应总发生率低于对照组,差异有统计学意义(P<0.05)。观察组不良心血管事件总发生率低于对照组,差异有统计学意义(P<0.05)。结论替格瑞洛在急性心肌梗死PCI术后抗血小板治疗中的效果显著,安全性较高,值得临床上推广使用。Objective To investigate the application effect of Ticagrelor in antiplatelet therapy after percutaneous coronary intervention(PCI)for acute myocardial infarction.Methods A total of 100 patients with acute myocardial infarction admitted to Xiangzhou District People′s Hospital of Xiangyang city from January 2019 to June 2020 were selected as the research objects,and were divided into observation group and control group according to random number table method,with 50 patients in each group.The observation group received Aspirin+Ticagrelor before and after PCI,and the control group received Aspirin+Clopidogrel before and after PCI.The platelet aggregation rate,liver function,the incidence of adverse reactions and the total incidence of adverse cardiovascular events in two groups were compared.Results There was no significant difference in platelet aggregation rate between the two groups before operation(P>0.05).The platelet aggregation rate of observation group at 2,24 h and 7 d after surgery were lower than those of control group,the differences were statistically significant(P<0.05).There was no significant difference in liver function between the two groups before surgery(P>0.05).The levels of glutamic-oxalacetic transaminase and serum creatinine in the observation group at 7 d after operation were higher than those before operation and those in the control group,the differences were statistically significant(P<0.05).The total incidence of adverse cardiovascular events in observation group was lower than that in control group,the difference was statistically significant(P<0.05).Conclusion Ticagrelor has a significant effect on antiplatelet therapy after PCI in acute myocardial infarction with high safety and is worthy of clinical promotion.In summary,ticagrelor is effective in antiplatelet therapy after PCI for acute myocardial infarction,and it is worthy of clinical application.

关 键 词：替格瑞洛 急性心肌梗死 经皮冠状动脉介入治疗手术 抗血小板治疗 氯吡格雷 

分 类 号：R542.22[医药卫生—心血管疾病]