药物涂层球囊在急性ST段抬高型心肌梗死中应用的有效性及安全性研究  

Study on the effectiveness and safety of drug-coated balloons in acute ST-segment elevation myocardial infarction

作　　者：马曹 杨新颖 吴晓光 史永恩 周豪杰 张卫杰 张凯 陶锋 郑晓晖 Ma Cao;Yang Xinying;Wu Xiaoguang;Shi Yongen;Zhou Haojie;Zhang Weijie;Zhang Kai;Tao Feng;Zheng Xiaohui(Emergency Department,Fuwai Central China Cardiovascular Hospital(Henan Provincial People's Hospital Heart Center),Zhengzhou 451464,China;不详)

机构地区：[1]阜外华中心血管病医院急诊科(河南省人民医院心脏中心),郑州451464 [2]河南省人民医院老年医学科,郑州451464

出　　处：《中国循证心血管医学杂志》2021年第8期999-1002,共4页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的探讨药物涂层球囊在急性ST段抬高型心肌梗死(STEMI)患者中应用的有效性及安全性。方法回顾性分析阜外华中心血管病医院明确诊断为STEMI并接受急诊介入治疗及有效随访患者106例,其中34例给予药物涂层球囊(DCB)治疗,72例给予药物洗脱支架(DES)治疗,随访10个月并复查冠状动脉(冠脉)造影,比较两组靶病变再血管化率(TLR)、靶血管再血管化率(TVR)、晚期管腔直径丢失率(LLL)及再发心绞痛、再发心肌梗死、心源性死亡、卒中等不良事件发生率。结果两组均无TVR事件发生,TLR相比无显著差异(2.9%vs.2.8%,P>0.05),晚期管腔直径丢失DCB组优于DES组[-(0.037±0.071)mm vs.(0.135±0.358)mm,P<0.05],差异有统计学意义,复查冠脉造影DCB组晚期最小管腔直径获得优于DES组,差异无统计学意义[(0.033±0.132)mm vs.-(0.041±0.535)mm,P>0.05],DCB组术后即刻残余狭窄劣于DES组[(9.76±5.064)%vs.(2.26±3.206)%,P<0.05],差异有统计学意义。结论药物涂层球囊在STEMI患者中的应用有效且相对安全。Objective To investigate the effectiveness and safety of drug-coated balloons in patients with acute ST-segment elevation myocardial infarction(STEMI).Methods A retrospective analysis of 106 patients in Fuwai Central China Cardiovascular Hospital who were clearly diagnosed as STEMI and received emergency interventional treatment and effective follow-up.Among them,34 patients were treated with drug coated balloon(DCB)and 72 patients were treated with drugs.The eluting stent(drug eluting stent,DES)treatment,followed up for 10 months and rechecked coronary angiography,compared the two groups of target lesion revascularization rate(target lesion revascularization rate,TLR),target vessel revascularization rate(target vessel revascularization rate,TVR),late lumen diameter loss rate(LLL)and the incidence of adverse events such as recurring angina,recurring myocardial infarction,cardiogenic death,and stroke.Results There was no TVR event in the two groups,and there was no significant difference in TLR(2.9%vs.2.8%,P>0.05).The late lumen diameter loss DCB group was better than the DES group[-(0.037±0.071)mm vs.(0.135±0.358)mm,P<0.05],the difference was statistically significant.The minimum lumen diameter obtained in the DCB group on reexamination of coronary angiography was better than that in the DES group,and the difference was not statistically significant[(0.033±0.132)mm vs.-(0.041±0.535)mm,P>0.05],the immediate residual stenosis in the DCB group was worse than that in the DES group[(9.76±5.064)%vs.(2.26±3.206)%,P<0.05],the difference was statistically significant.Conclusion The application of drug-coated balloons in STEMI patients is effective and relatively safe.

关 键 词：药物涂层球囊 药物洗脱支架 急性ST段抬高型心肌梗死 有效性 安全性 

分 类 号：R542.22[医药卫生—心血管疾病]