孟鲁司特及布地奈德对支气管哮喘患者TNF-α、IL-5、肺功能及生活质量的影响  

Effect of montelukast and budesonide on TNF-alpha,IL-5,pulmonary function and quality of life in patients with bronchial asthma

作　　者：闫梅[1] YAN Mei(The Second Department of Respiratory Diseases,Affiliated Hospital of Jining Medical College,Jining 272029,China)

机构地区：[1]济宁医学院附属医院呼吸内二科,山东济宁272029

出　　处：《吉林医学》2021年第8期1848-1850,共3页Jilin Medical Journal

摘　　要：目的:观察孟鲁司特及布地奈德对支气管哮喘患者TNF-α、IL-5、肺功能及生活质量的影响。方法:选取轻中度哮喘患者90例,随机分为A组、B组及C组,A组患者予吸入布地奈德干粉剂治疗,B组予口服孟鲁司特钠片治疗,C组患者予吸入布地奈德干粉剂及口服孟鲁司特钠片治疗。所有患者均采用耶格肺功能仪进行肺功能测定,酶联免疫吸附实验法测定血清中肿瘤坏死因子α(TNF-α)和白细胞介素5(IL-5)的浓度。采用圣-乔治呼吸问卷(SGRQ)评价生活质量,测定三组患者治疗前后生活质量评分、FEV_(1)、PEF、TNF-α及IL-5水平差异。结果:所有哮喘患者治疗后血清TNF-α及IL-5水平明显降低,而孟鲁司特与布地奈德联合治疗组TNF-α及IL-5水平明显低于单药治疗组。哮喘患者治疗后,FEV_(1)及PEF较治疗前明显升高,而孟鲁司特与布地奈德联合治疗组FEV_(1)及PEF明显高于单药治疗组。哮喘患者治疗后,生活质量评分较治疗前改善,而孟鲁司特与布地奈德联合治疗组优于单药治疗组。结论:孟鲁司特联合布地奈德治疗可明显改善哮喘患者生活质量,改善血清炎性介质水平,改善肺功能。Objective To explore effect of montelukast and budesonide on TNF-alpha,IL-5,pulmonary function and quality of life in patients with bronchial asthma.Method 90 patients with bronchial asthma were divided into group A(n=30),group B(n=30)and group C(n=30)randomly.Patients in group A were treated with budesonide.Patients in group B were treated with montelukast.Patients in group C were treated with montelukast and budesonide.TNF-alpha,IL-5,pulmonary function and quality of life were measured by yeager lang function in strument.SGRQ was used to evaluate the quality of life.The scores of quality of life,FEV_(1)、PEF、TNF-α、IL-5 were measured before and after treatment.Results FEV_(1) and PEF were increased after treatment,and FEV_(1) and PEF in group C were significantly higher than those in group A and B.Level of TNF-alpha and IL-5 were decreased after treatment,and Level of TNF-alpha and IL-5 in group C were significantly lower than those in group A and B.Quality of life improved after treatment,and the combined treatment group was superior to the single drug treatment group.Conclusion Treatment of montelukast combined with budesonide could significantly improve the serum levels of inflammatory mediators,improve lung function and improve quality of life in patients with asthma.

关 键 词：哮喘 孟鲁司特 布地奈德 生活质量 肺功能 肿瘤坏死因子α 白细胞介素-5 

分 类 号：R562.25[医药卫生—呼吸系统]