复方氨酚烷胺胶囊致大疱性表皮松解型药疹  

Epidermolysis bullosa type eruption due to compound paracetamol and amantadine hydrochloride capsules

作　　者：吴晓平 孙晓静[2] 李进峰 Wu Xiaoping;Sun Xiaojing;Li Jinfeng(Department of Pharmacy,Weihai Municipal Hospital,Cheeloo College of Medicine,Shandong University,Shandong Province,Weihai 264200,China;Department of Dermatology,Weihai Municipal Hospital,Cheeloo College of Medicine,Shandong University,Shandong Province,Weihai 264200,China)

机构地区：[1]山东大学附属威海市立医院药剂科,威海264200 [2]山东大学附属威海市立医院皮肤科,威海264200

出　　处：《药物不良反应杂志》2021年第7期381-383,共3页Adverse Drug Reactions Journal

摘　　要：1例52岁男性患者因感冒自行服用复方氨酚烷胺胶囊(每粒含对乙酰氨基酚250 mg,盐酸金刚烷胺100 mg、马来酸氯苯那敏2 mg、人工牛黄10 mg、咖啡因15 mg)1粒,用药半日后出现背部红斑伴瘙痒。次日皮疹加重,遍及全身,累及口腔、眼睛、阴囊黏膜,并逐渐发展为大疱疹,表皮脱落,皮损面积达90%,伴轻度肝损伤和血糖升高,诊断为大疱性表皮松解坏死型药疹。经大剂量糖皮质激素、免疫球蛋白及对症支持治疗,3周后皮损基本痊愈。考虑患者的大疱性表皮松解坏死型药疹很可能与复方氨酚烷胺胶囊中的对乙酰氨基酚相关。A 52‑year‑old male patient took one compound paracetamol and amantadine hydrochloride capsule(each capsule contains 250 mg acetaminophen,100 mg amantadine hydrochloride,2 mg chlorphenamine maleate,10 mg artificial bezoar,and 15 mg caffeine)by himself for a cold.Half a day after the medication,the patient developed erythema with itching on the back.The next day the rash worsened and spread throughout the body,involving the mouth,eyes,and scrotal mucosa.Then the skin rash developed into big herpes with epidermal sloughing,and the area of skin damage reached to 90%,accompanied by mild liver injury and blood glucose rise.Epidermolysis bullosa type eruption was diagnosed.High‑dose glucocorticoids,immunoglobulins,and symptomatic and supportive treatments were given and her skin lesions largely recovered 3 weeks later.The patient′s epidermolysis bullosa type eruption was considered to be probably related to the acetaminophen in compound paracetamol and amantadine hydrochloride capsules.

关 键 词：对乙酰氨基酚 金刚烷胺 氯苯那敏 咖啡因 大疱性表皮松解 

分 类 号：R969[医药卫生—药理学]