尿激酶联合臭氧序贯冲洗辅助治疗结核性包裹性胸腔积液的临床效果  

Clinical effect of urokinase combined with ozone sequential irrigation in the treatment of tuberculous encapsulated pleural effusion

作　　者：陈柳坚 朱吉生 占劲松 崔芳芳 CHEN Liujian;ZHU Jisheng;ZHAN Jinsong;CUI Fangfang(Department of Infection,Gucheng People's Hospital,Xiangyang,Hubei,441700,China)

机构地区：[1]谷城县人民医院感染科,湖北襄阳441700

出　　处：《当代医学》2021年第23期63-65,共3页Contemporary Medicine

摘　　要：目的探讨尿激酶联合臭氧序贯冲洗方案辅助治疗结核性包裹性胸腔积液的疗效及安全性。方法选取本院2016年1月至2017年12月收治的100例结核性包裹性胸腔积液患者,根据随机数字表法分为对照组和观察组,各50例。在置管引流基础上,对照组采用单纯尿激酶冲洗方案,观察组采用臭氧联合尿激酶序贯冲洗方案治疗。比较两组患者临床疗效、康复情况、病理及功能水平及药物不良反应发生情况。结果观察组治疗总有效率高于对照组,置管引流时间、胸腔积液消失时间及住院时间均短于对照组,胸膜厚度小于对照组,胸腔积液蛋白质及白细胞(WBC)计数低于对照组,差异均有统计学意义(P<0.05)。两组患者药物不良反应发生率比较差异无统计学意义。结论尿激酶联合臭氧序贯冲洗方案辅助治疗结核性包裹性胸腔积液安全性较高,且疗效优于单纯尿激酶方案,值得临床推广应用。Objective To investigate the clinical effect and safety of urokinase combined with ozone sequential irrigation in the treatment of tuberculous encapsulated pleural effusion.Methods 100 patients with tuberculous encapsulated pleural effusion were selected from January 2016 to December 2017 in our hospital and they were randomly divided into control group and observation group,with 50 cases in each group.On the basis of tube drainage,the control group was treated with simple urokinase irrigation,and the observation group was treated with ozone combined with se-quential urokinase irrigation.The clinical efficacy,rehabilitation,pathological and functional level,adverse drug reactions were compared between two groups.Results The clinical effects for short-term of observation group were significant higher than control group,the drainage time,the disap-pearance time of pleural effusion and the hospitalization time of observation group after treatment were significant shorter than control group;the pleural thickness and the levels of pleural effusion protein and WBC count of observation group after treatment were significant less than control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion Urokinase combined with ozone sequential irrigation is safe and effective in the treatment of tuberculous encapsulated pleural effusion,which is worthy of clinical application.

关 键 词：胸腔积液 结核 尿激酶型纤溶酶原激活剂 臭氧 引流术 

分 类 号：R521.7[医药卫生—内科学]