福美加联合钙尔奇D对绝经后骨质疏松患者骨密度及骨转换标志物的影响  

Effects of Formega and Calci D on bone mineral density and bone turnover markers in postmenopausal osteoporosis patients

作　　者：唐华 张钟元 陈思历 廖君 牛玉林 TANG Hua;ZHANG Zhongyuan;CHEN Sili;LIAO Jun;NIU Yulin(The Second Department of Orthopedics,Sichuan Modern Hospital,Chengdu,Sichuan,610000,China)

机构地区：[1]四川现代医院骨科二病区,四川成都610000

出　　处：《当代医学》2021年第23期78-80,共3页Contemporary Medicine

摘　　要：目的研究福美加联合钙尔奇D对绝经后骨质疏松症患者骨密度及骨转换标志物的影响。方法选取2017年3月至2018年12月本院收治的绝经后骨质疏松症患者72例作为研究对象,所有患者均给予福美加联合钙尔奇D治疗。比较治疗前及治疗后3、6、12个月Wards三角、股骨颈、L2~4等不同部位的骨密度,P1NP和β-CTx等骨转换标志物水平,ALP、血磷、血钙等血生化指标及用药期间不良反应发生情况。结果治疗后3、6、12个月,Wards三角、股骨颈和L_(2~4)等部位的骨密度均明显高于治疗前,差异均有统计学意义(P<0.05);治疗后6、12个月,各部位骨密度均明显高于治疗后3个月,差异有统计学意义(P<0.05);治疗后12个月,各部位骨密度均明显高于治疗后6个月,差异有统计学意义(P<0.05);各部位骨密度随时间均呈升高趋势,组间比较差异有统计学意义(P<0.05)。治疗后3、6、12个月,P1NP和β-CTx均明显低于治疗前,治疗后6、12个月明显低于治疗后3个月,治疗后12个月明显低于治疗后6个月,差异均有统计学意义(P<0.05);P1NP和β-CTx随着时间均呈下降趋势,组间比较差异有统计学意义(P<0.05)。治疗后3、6、12个月,ALP明显低于治疗前,治疗后6、12个月均明显低于治疗后3个月,治疗后12个月明显低于治疗后6个月,差异有统计学意义(P<0.05);ALP随时间呈下降趋势,且组间比较差异有统计学意义(P<0.05)。治疗后3、6、12个月,血磷和血钙与治疗前比较差异无统计学意义。治疗中患者出现便秘1例,恶心呕吐2例,无骨折、肝、肾损害发生。结论绝经后骨质疏松患者采用钙尔奇D联合福美加治疗可降低P1NP、β-CTx水平,增加各部位骨密度,改善骨质疏松症,安全性较高,值得临床推广运用。Objective To study the effect of Formica and Calci D on bone mineral density and bone turnover markers in postmenopausal osteo-porosis patients.Methods A total of 72 patients with postmenopausal osteoporosis who were treated in our hospital from March 2017 to December 2018 were selected as the research subjects,all patients were treated with Formica and Calci D.The bone density in different parts such as Wards triangle,femoral neck,L_(2-4),etc,levels of bone turnover markers such as P1NP and β-CTx,blood biochemical indicators such as ALP,blood phos-phorus,blood calcium and adverse reactions during medication were compared before treatment,3 months,6 months,12 months after treatment.Results The bone density of Wards triangle,femoral neck,and L_(2-4)at 3 months,6 months,and 12 months after treatment were significantly higher than before treatment,with significant difference(P<0.05).Bone density in various parts at 6 months and 12 months after treatment were significantly higher than 3 months after treatment,and there was statistical significant diffrence(P<0.05).Bone density in variou parts at 12 months after treat-ment were significantly higher than that 6 months after treatment,and there was statistical significant difference(P<0.05).Bone density in variou parts showed an increasing trend with time,with statistical significant difference(P<0.05).P1NP and β-CTx at 3 months,6 months,and 12 months after treatment were significantly lower than before treatment,and there was statistical difference(P<0.05).P1NP and β-CTx at 6 months and 12 months after treatment were significantly lower than before treatment,and there was statistical difference(P<0.05).P1NP and β-CTx at 12 months after treatment were significantly lower than before treatment,and there was statistical difference(P<0.05).Both P1NP and β-CTx showed a downward trend with time,with statistical significant difference(P<0.05).ALP were significantly lower at 3 months,6 months,and 12 months after treatment than before treatment,with statistical significant

关 键 词：福美加 钙尔奇 绝经 骨质疏松 骨转换标志物 骨密度 

分 类 号：R580[医药卫生—内分泌]