Ionic liquid catalyzed solvent-free synthesis of chalcone and its derivatives under mild conditions  

作　　者：Qiu Zhao Gang Wang Fuxia Liao Yifan Sha Fei Xu Chunshan Li Zengxi Li Yijun Cao 

机构地区：[1]School of Chemical Engineering and Energy,Zhengzhou University,Zhengzhou 450001,China [2]Key Laboratory of Green Process and Engineering,State Key Laboratory of Multiphase Complex Systems,Beijing Key Laboratory of Ionic Liquids Clean Process,Institute of Process Engineering,Chinese Academy of Sciences,Beijing 100190,China [3]School of Chemical Sciences,University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Chinese Journal of Chemical Engineering》2021年第5期160-166,共7页中国化学工程学报（英文版）

基　　金：We thank the financial support of Major Program of National Natural Science Foundation of China(21890762);General Program of National Natural Science Foundation of China(21878293);National Natural Science Foundation of China(21676270);Key Research Program of Frontier Sciences,CAS(QYZDY-SSW-JSC011);the K.C.Wong Education Foundation(GJTD-2018-04).

摘　　要：An ionic liquid(IL)catalyzed solvent-free process was developed for the direct synthesis of chalcone and its derivatives by using substituted acetophenones and benzaldehydes via aldol reaction under mild conditions.A series of acidic and basic ILs were selected and screened.The influences of cations and reaction conditions on product yield and selectivity were systematically investigated.The[Bmim]OH was identified as the optimal IL,with the highest yield and selectivity reaching up to 96.7% and 100%,respectively.A reaction mechanism-based kinetic model was established and regressed with experimental data,revealing the β-Hydroxylketone dehydrolysis with activation barrier of 37.8 kJ·mol^(-1) was observed as the ratecontrolling step.

关 键 词：IONIC liquid CHALCONE ALDOL reaction KINETIC model 

分 类 号：TQ244.2[化学工程—有机化工]