利巴韦林结合清热解毒方对流行性腮腺炎热毒壅盛证患儿血清SAA、淀粉酶及症状消除时间的影响  

Effect of ribavirin combined with Qingrejiedu Recipe on serum SAA, amylase and symptom elimination time in epidemic parotitis children with pattern of heat-toxin congestion and excessiveness

作　　者：孙欣娜 胡正权[1] 成佳文 杨青[1] 杨茜芸 张世娜 SUN Xin-na;HU Zheng-quan;CHENG Jia-wen;YANG Qing;YANG Xi-yun;ZHANG Shi-na(Department of Pediatrics,Hebei No.7 People’s Hospital(Second Affiliated Hospital of Hebei College of Traditional Chinese Medicine),Dingzhou 073000,China)

机构地区：[1]河北省第七人民医院(河北中医学院第二附属医院)儿科,定州073000

出　　处：《传染病信息》2021年第4期335-337,377,共4页Infectious Disease Information

基　　金：2018年度医学科学研究重点课题计划(20180960)。

摘　　要：目的观察利巴韦林结合清热解毒方治疗流行性腮腺炎热毒壅盛证患儿的临床效果,探究其对血清淀粉样蛋白A(serum amyloid A protein, SAA)及淀粉酶的影响。方法选取我院2016年4月-2019年9月收治的82例流行性腮腺炎患儿为研究对象。用随机数字表法分为观察组和对照组(每组41例),对照组予以利巴韦林治疗,观察组在对照组基础上服用清热解毒方。比较2组患儿发热、腮腺肿胀、腺体疼痛等症状体征的消失时间、住院时间、临床疗效、不良反应和SAA及淀粉酶水平。结果观察组各症状消失时间、住院时间均显著短于对照组(P均<0.05)。观察组、对照组症状缓解的总有效率分别为95.12%、80.49%,观察组显著高于对照组(P <0.05)。治疗后,2组患儿血清SAA、总淀粉酶、唾液型淀粉酶水平均显著下降,且观察组血清SAA、总淀粉酶、唾液型淀粉酶下降水平均显著高于对照组,差异均有统计学意义(P均<0.05);观察组和对照组不良反应发生率分别为7.32%和9.76%,2组比较差异无统计学意义(P> 0.05)。结论采用利巴韦林结合清热解毒方治疗流行性腮腺炎热毒壅盛证患儿,可以降低血清SAA和淀粉酶水平,改善腮腺肿痛,缓解临床症状,缩短治疗时间,值得临床推广。Objective To observe the clinical effect of ribavirin combined with Qingrejiedu Recipe in treating epidemic parotitis children with pattern of heat-toxin congestion and excessiveness, and to explore its effects on serum amyloid A protein(SAA)and amylase. Methods From April 2016 to September 2019, 82 children with epidemic parotitis in our hospital were selected as the research objects. They were divided into observation group and control group by using random number method, with 41 cases in each group. The control group was treated with ribavirin, and the observation group was given Qingrejiedu Recipe on the base of the control group. The extinction time of symptoms and signs(fever, parotid gland swelling, gland pain), length of hospital stay, clinical curative effect, adverse reaction, the levels of SAA and amylase of children in 2 groups were compared. Results The extinction time of symptoms and the length of hospital stay of the observation group were significantly shorter than those of the control group(P <0.05).The overall response rates of symptom relief in observation group and control group were 95.12% and 80.49%, respectively, and the rate in observation group was significantly higher than that in control group(P <0.05). After treatment, SAA, total amylase and salivary amylase levels of children in 2 groups were significantly declined, and the decline in the observation group was significantly higher than that in the control group. The differences were statistically significant(P <0.05). The incidences of adverse reactions in observation group and control group were 7.32% and 9.76%, respectively, without significant difference(P >0.05). Conclusions Ribavirin combined with Qingrejiedu Recipe can reduce the levels of SAA and amylase, improve the swelling and pain of parotid gland,alleviate clinical symptoms and shorten the treatment time in children with epidemic parotitis with pattern of heat-toxin congestion and excessiveness, which is worthy of clinical promotion.

关 键 词：流行性腮腺炎 清热解毒方 利巴韦林 血清淀粉样蛋白A 

分 类 号：R512.1[医药卫生—内科学] R725.1[医药卫生—临床医学]