疟原虫在人体内发育过程的研究进展  

Progress in development of Plasmodium in human body

作　　者：姚鹏飞 张鹏江 孙杨 YAO Peng-fei;ZHANG Peng-jiang;SUN Yang(Neurosurgery Department,The 940th Hospital of Joint Logistics Support Force of PLA,Lanzhou 730050,China)

机构地区：[1]中国人民解放军联勤保障部队第九四〇医院神经外科,兰州730050 [2]中国人民解放军联勤保障部队第九四〇医院呼吸科,兰州730050 [3]中国人民解放军联勤保障部队第九四〇医院妇科,兰州730050

出　　处：《传染病信息》2021年第4期369-372,共4页Infectious Disease Information

基　　金：甘肃省科技计划资助(1506RJZA304)。

摘　　要：疟疾是由疟原虫引起的虫媒传染病,在全球尤其是热带地区肆虐流行,严重威胁着人类的健康。疟原虫主要在人类宿主体内发育繁殖,具有复杂的生命周期,包括疟原虫入侵、迁移、逃避免疫攻击、肝细胞内分裂增殖、入侵红细胞并在红细胞内大量繁殖、周期性释放等系列过程,最终导致疟疾患者症状周期性发作。本文重点围绕疟原虫(即子孢子、裂殖子)人体红细胞外、红细胞内入侵及发育过程的研究进展进行综述,为疟疾疫苗研发和疟疾防控救治提供参考。Malaria is an insect-borne infectious disease caused by Plasmodium, which is endemic around the world, especially in the tropics, and it poses a serious threat to human health. Plasmodium mainly develops and reproduces in the human hosts and exhibits a complex life cycle, involving a series of processes such as the Plasmodium invasion, migration, escape of immune attack, division and proliferation in the hepatocytes, invading and multiplying in red blood cells, and periodical release, which ultimately results in periodic outbreaks of malaria symptoms in patients. This review focuses on the research progress of the exoerythrocytic and endoerythrocytic invasion and development of Plasmodium(sporozoite, merozoite) in human body, and provides references for the development of antimalarial vaccines and the prevention and treatment of malaria.

关 键 词：疟疾 恶性疟原虫 子孢子 裂殖子 人类宿主 红细胞外期 红细胞内期 发育 

分 类 号：R382.31[医药卫生—医学寄生虫学]