循环circRNA MICRA水平在AMI患者中的变化及临床意义  

Level and Value of circRNA MICRA in Patients with Acute Myocardial Infarction

作　　者：郑俊晨[1] 周晓林 ZHENG Jun-chen;ZHOU Xiao-Lin(Yanan University Affiliated Hospital,Yanan Shaanxi 716000)

机构地区：[1]延安大学附属医院东关分院,陕西延安716000 [2]宝鸡西机医院,陕西宝鸡722400

出　　处：《医学临床研究》2021年第7期1045-1047,共3页Journal of Clinical Research

摘　　要：[目的]探讨AMI患者循环circRNA MICRA水平变化及其临床意义。[方法]选择2017年1月至2018年5月本院收治的73例AMI患者的临床资料(观察组),同时选择同期于本院健康体检的73例健康志愿者(对照组)。入组即刻抽取所有入选者外周血备用,检测循环circRNA MICRA水平,同时AMI患者出院后均随访6个月,记录主要不良心血管事件(MACE),比较两组受试者MICRA水平差异及MICRA水平与AMI预后的相关性。[结果]观察组循环MICRA水平为1.63±0.28,显著低于对照组的2.97±0.74.差异有统计学意义(1=14.470,P<0.01)。ROC评估MICRA作为AMI诊断标记物的效能显示,其曲线下面积(AUC)(95%CI)为0.81(0.73~0.90),最佳诊断界值为1.47。预后不良组患者循环MICRA为0.87±0.22,显著低于预后良好组患者2.19±0.85,差异有统计学意义(t=12.845,P<0.01)。[结论]循环circRNA MICRA在AMI患者中表达下调,同时与AMI患者预后密切相关,是潜在的诊断及评估AMI患者的生物学标记物。[Objective]To analyze the level of circRNA MICRA in patients with acute myocardial infarction(AMI)and its clinical significance.[Methods]A total of 73 patients with AMI who were diagnosed in the department of cardiolo-gy from January 2017 to May 2018 were enrolled as the AMI group and 73 healthy volunteers examined in the same time period in our hospital were included as healthy controls(HC)group.Venous blood was drawn from subjects immediately at admission to detect level of circRNA MICRA,and AMI patients were followed up 6 months after discharge and the major adverse cardiovascular events(MACE)in the group were recorded.MICRA levels were compared between the AMI and HC groups to explore the difference in level and the correlation between level of MICRA and AMI condition and prog-nosis.[Results]Compared to the HC group,the level of MICRA in AMI group was significantly reduced[(1.63±0.28)vs(2.97±0.74),t=14.470,P<0.01];Receiver Operation Characterist Curve(ROC)evaluation of the effectiveness of MICRA as a diagnostic marker for AMI showed that the area under the curve(AUC)(95%CI)was 0.81(0.73-0.90)and the cutoff value was 1.47.Compared to patients with good prognosis,patients with poor prognosis had lower MICRA lev-els[(0.87±0.22)vs(2.19±0.85),t=12.845,P<0.01].[Conclusion]Level of MICRA was down regulated in AMI patients and was closely related to AMI patient prognosis.It is a potential biomarker for the diagnosis and evaluation of AMI patients.

关 键 词：心肌梗死/遗传学 急性病 生物标记 预后 

分 类 号：R542.22[医药卫生—心血管疾病]