某三甲医院2010〜2020年胆道感染细菌的变迁及对抗菌药物敏感性分析  

Distribution of changes in antimicrobial resistance of with biliary infection in a tertiary hospital during 2010〜2020

作　　者：朱虹[1] 袁孔现[1] ZHU Hong;YUAN Kong-xian(Tongling People's Hospital,Tongling 244000)

机构地区：[1]安徽省铜陵市人民医院药学部,铜陵244000

出　　处：《肝胆外科杂志》2021年第3期217-220,共4页Journal of Hepatobiliary Surgery

摘　　要：目的了解在《抗菌药物临床应用指导原则》(2015版)实施前后胆汁中感染细菌群变化及其对抗菌药物的敏感性变化。方法分别将2010年1月至2015年12月和2016年1月至2020年12月培养阳性的718例胆汁标本共937株病原菌及药敏结果进行回顾性分析。结果与《抗菌药物临床应用指导原则》(2015版)实施前比较,2016年后大肠埃希菌、阴沟肠杆菌、粪肠球菌的占比降低,克雷伯菌、铜绿假单胞菌、屎肠球菌、凝固酶阴性葡萄球菌占比增加。结论胆道感染菌种在增加,菌群在变迁,细菌耐药率在上升,临床应根据药敏试验结果合理选用抗菌药物。Objective To investigate the distribution of changes in antimicrobial resistance of pathogens with biliary ifection beforeand after ten-year implementation of the Guiding Principles of Clinical Application of Antibacterials(Edition 2015)(hereinafer referred to as“New Guiding Principles”).Methods To retrospectively analyze the results of 937 strains of bacteria from 718 bile specimens with positive culture and their susceptibility to antibiotics before(during 2010~2015)and after(during 2016~2020)the implementation of“New Guiding Principles”.Results Compare to before New Guiding Principleswas implemented,the proportion of Escherichia coli,Enterobactercloacae and Enterococcus facalis decreased,while the proportion of Klebsiella,Pseudomonas aerugino-sa,Enterococcus faeciumand Coagulase-negative Staphylococcusincreased.Conclusion There was a change of pathogen category in the biliary infections over the past years.Antimicrobialsusceptability results could be considered in choosing appropritedurg to avoid bacterial resistance.

关 键 词：胆道感染 病原菌 药敏试验 耐药率 抗菌药物 

分 类 号：R657.4[医药卫生—外科学]