疏郁化痰法对围绝经期失眠症患者血脂代谢和炎症因子的影响  

The effects of the Shuyu Huatan therapy on blood lipid metabolism and inflammatory factors in patients with perimenopausal insomnia

作　　者：陈燕芬 卢军 周春泉 张伯涛 秦育滨 林仰锦 林云奇 郑腊阳 Chen Yanfen

机构地区：[1]普宁市中医医院,广东普宁515300

出　　处：《中医临床研究》2021年第13期66-69,共4页Clinical Journal Of Chinese Medicine

基　　金：广东省教育厅临床教学基地教学改革研究项目(2018JD092);广东省中医药局面上项目(20201413);广东省揭阳市科技创新项目(2018wsyl046)

摘　　要：目的:观察疏郁化痰法对围绝经期失眠症患者的血脂代谢和炎症因子的影响。方法:将60例肝郁化火型围绝经期失眠症患者随机分为对照组和观察组,每组各30例。对照组给予克龄蒙联合右佐匹克隆治疗,观察组接受中药夏仙逍遥饮治疗。比较两组患者治疗前后的血清总胆固醇(Total cholesterol,TC)、三酰甘油(Triglycerides,TG)、低密度脂蛋白胆固醇(LDLCholesterol,LDL-CH)、瘦素(Leptin,LP)、脂联素(Adiponection,ADPN)、游离脂肪酸(Free Fatty Acid,FFA)和C反应蛋白(C-reactive Protein,CRP)、白细胞介素-6(Interleukin-6,IL-6)。结果:治疗后两组患者TC、TG均明显下降(P<0.05),且观察组降低程度优于对照组(P<0.05);治疗后,两组LDL-CH均不同程度下降,但对照组LDL-CH下降不明显(P>0.05),观察组LDL-CH下降明显(P<0.05)。治疗后两组患者LP、FFA均明显下降(P<0.05),且观察组降低程度优于对照组(P<0.05);治疗后两组ADPN明显升高,且观察组升高程度优于对照组(P<0.05)。治疗后两组患者CRP、IL-6均明显下降(P<0.05),且观察组降低程度优于对照组(P<0.05)。结论:夏仙逍遥饮可以改善围绝经期失眠症患者的脂质代谢,抑制炎症因子的表达,其具体的药理作用值得进一步研究。Objective:To observe the effects of the Shuyu Huatan therapy(疏郁化痰法)on blood lipid metabolism and inflammatory factors in patients with perimenopausal insomnia.Methods:60 cases were randomly divided into the control group and the observation group,30 cases in each.The control group was treated with CLIMEN(克龄蒙)plus dexzopiclone tablets,and the observation group was treated with the Xiaxian Xiaoyao decoction(夏仙逍遥饮).Results:After treatment,TC and TG in the groups were significantly decreased(P<0.05),and the degree of reduction in the observation group was better than the control group(P<0.05).After treatment,LDL-CH in the groups was decreased to varying degrees,the degree of reduction in the control group was not significant,but LDL-CH in the observation group was decreased significantly(P<0.05).LP and FFA in the groups were significantly decreased(P<0.05),and the decrease in the observation group was better than the control group(P<0.05).ADPN in the groups was significantly increased after treatment,and the increase in the observation group was better than the control group(P<0.05).CRP and IL-6 in the groups were significantly decreased(P<0.05),and the degree of reduction in the observation group was better than the control group(P<0.05).Conclusion:The Xiaxian Xiaoyao decoction can ameliorate blood lipid metabolism and inhibit the expression of inflammatory factors in patients with perimenopausal insomnia,and its specific pharmacological effects deserve further study.

关 键 词：围绝经期 睡眠障碍 失眠症 脂代谢 炎症因子 

分 类 号：R256.23[医药卫生—中医内科学]