孕妇血清皮质醇与足月分娩启动的相关性研究  

Study on the Correlation between Pregnant Women′s Serum Cortisol and the Initiation of Full-Term Labor

作　　者：伍怡 柴语鹃 董晓静[1] WU Yi;CHAI Yujuan;DONG Xiaojing(Department of Obstetrics and Gynecology,The Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China;School of Biomedical Engineering,Health Science Center,Shenzhen University,Shenzhen Guangdong 518000,China)

机构地区：[1]重庆医科大学附属第二医院妇产科,重庆400010 [2]深圳大学医学部生物医学工程学院,广东深圳518000

出　　处：《实用妇产科杂志》2021年第7期527-530,共4页Journal of Practical Obstetrics and Gynecology

基　　金：重庆市自然科学基金(编号:CSTC2019jcyj-msxmX0318);深圳市高端人才科研启动基金(编号:827/000511)。

摘　　要：目的:探讨血清皮质醇水平与足月分娩临产启动的相关性。方法:选择2019年10月1日至2020年4月30日在重庆医科大学附属第二医院行规律产前检查并于产科住院分娩的足月妊娠未临产孕妇(待产组71例)、足月妊娠先兆临产(先兆临产组30例)及临产孕妇(临产组30例),及同时间段正常体检的同年龄段、育龄期非孕女性(对照组65例)为研究对象,运用量子点免疫层析法测定并比较其血清皮质醇;采用Spearman对先兆临产孕妇血清皮质醇与临产时间的相关性进行分析;以阴道检查结果作为金标准,计算血清皮质醇预测临产的诊断效能。结果:对照组、待产组、先兆临产组及临产组的血清皮质醇浓度分别为68(44,96)μg/L、164(144,196)μg/L、190(150,210)μg/L、480(396,600)μg/L,其中,对照组的血清皮质醇浓度明显低于其他3组(P<0.05),临产组的血清皮质醇浓度明显高于其他3组(P<0.05),待产组和先兆临床组的血清皮质醇浓度差异无统计学意义(P>0.05)。先兆临产组孕妇血清皮质醇浓度与采血至临产时间之间无明显相关性(r=0.019,P=0.925)。当孕妇血清皮质醇浓度>254μg/L时,判断其临产的特异度为96.7%,敏感度为90.0%。结论:足月待产组孕妇血清皮质醇明显高于同年龄段非孕妇女,临产后孕妇血清皮质醇迅速升高,有望成为判断临产的快速诊断指标。Objective:To explore the relationship between serum cortisol levels and the initiation of full-term labor.Methods:Selected non-pregnant women of childbearing age(65 cases in the control group)and full-term pregnancy who underwent regular antenatal checkups at the Second Affiliated Hospital of Chongqing Medical University from October 1,2019 to April 30,2020 and were hospitalized in obstetrics.The full-term pregnancy were divided into expectant labor group(pregnant women who were not in labor,71 cases),threatened labor group(pregnant women who were suffering thretened labor,30),and labor group(pregnant women who were in labor,30 cases).Quantum dot immunochromatography is used to measure and compare their serum cortisol;Spearman was used to analyze the correlation between serum cortisol of threatened labor women and the time of labor.Predictive value of the serum cortisol in pregnant women are compared with the results of vaginal examination,which is the gold standard.Results:The serum cortisol concentrations of the control group,expectant labor group,threatened labor group and labor group were 68(44,96)μg/L,164(144,196)μg/L,190(150,210)μg/L,and 480(396,600)μg/L,respectively.The serum cortisol concentration of the control group was significantly lower than the other 3 groups(P<0.05),and the serum cortisol concentration of the labor group was significantly higher than the other 3 groups(P<0.05).There was no significant difference in serum cortisol concentration between the expectant labor group and the threatened labor group(P>0.05).There was no significant correlation between the serum cortisol concentration of pregnant women in the threatened labor group and the time from blood collection to labor(r=0.019,P=0.925).When the serum cortisol concentration of pregnant women was more than 254μg/L,the specificity for judging labor was 96.7%,and the sensitivity was 90.0%.Conclusions:The serum cortisol of full-term pregnant women is significantly higher than that of non-pregnant women of the same age.The serum cortiso

关 键 词：足月待产 先兆临产 临产 血清皮质醇 

分 类 号：R714.3[医药卫生—妇产科学]