唾液腺腺样囊性癌中外泌体功能的研究进展  

Research progress of exosome functions in salivary adenoid cystic carcinoma

作　　者：于晶晶 孟颖 叶金海[1] YU Jingjing;MENG Ying;YE Jinhai(Key Laboratory of Oral Disease Research,Narjing Medical Universily,Department of Oral and Marillofacial Surgery,Afiliated Stomatological Hospial of Nanjing Medical Unirersity,Nanjing 210029,China)

机构地区：[1]南京医科大学口腔疾病研究江苏省重点实验室,南京医科大学附属口腔医院口腔颌面外科,江苏南京210029

出　　处：《口腔医学》2021年第7期664-668,共5页Stomatology

基　　金：江苏高校优势学科建设工程(2018-87);江苏省“科教强卫工程”医学重点人才项目(ZDRCA2016087)。

摘　　要：唾液腺腺样囊性癌(SACC)是一种临床常见的唾液腺恶性肿瘤。该肿瘤往往生长缓慢,具有高度嗜神经特性,侵袭性强并易入侵血管,导致血行转移。近年来,对该病的发病机制和分子表型的研究取得了一些进展。多种体外实验方法的运用,使研究人员逐渐认识到外泌体在实体肿瘤的增殖、迁移和侵袭中起重要作用,进一步探究关于外泌体在腺样囊性癌中的功能具有重要意义,可为腺样囊性癌的发病机制研究开拓新思路。Salivary adenoid cystic carcinoma(SACC)is a common clinical malignancy of salivary glands.The tumor tends to grow slowly,has a highly neurotropic character,is aggressive and easily invades blood vessels,leading to hematogenous metastasis.In recent years,some advances have been made in the study of the pathogenesis and molecular phenotype of the disease.With the application of various in vitro experimental methods,researchers have gradually realized that exosomes play an important role in the proliferation,migration and invasion of solid tumors.It is of great significance to further explore the function of exosomes in adenoid cystic carcinoma,which can open up new ideas for research on the pathogenesis of adenoid cystic carcinoma.

关 键 词：外泌体 唾液腺腺样囊性癌 增殖 嗜神经侵袭 促血管生成 

分 类 号：R329.28[医药卫生—人体解剖和组织胚胎学] R739.87[医药卫生—基础医学]