火针与薄芝糖肽注射液局部注射治疗局限性硬皮病的疗效比较  

Comparison of the efficacy of fire acupuncture and local injection of Bozhi glycopeptide in the treatment of localized scleroderma

作　　者：王红[1] 韩慧[1] 吴霞[1] Wang Hong;Han Hui;Wu xia

机构地区：[1]包头医学院第二附属医院,内蒙古包头014030

出　　处：《中医临床研究》2021年第12期105-107,110,共4页Clinical Journal Of Chinese Medicine

基　　金：包头市科技计划项目(2019z3011-06)。

摘　　要：目的:比较火针与薄芝糖肽注射液治疗局限性硬皮病的临床疗效。方法:将包头医学院第二附属医院在2018年1月-2019年12月收治的60例局限性硬皮病患者作为研究对象,将其随机分为两组,其中对照组30例,观察组30例,对照组患者使用薄芝糖肽注射液治疗,观察组患者使用火针外治,比较两组患者治疗总有效率、治疗前后结缔组织生长因子(Connective Tissue Growth Factor,CTGF)水平、转化生长因子-β1(Transforming Growth Factor-β1,TGF-β1)水平、中医证候评分、皮损程度。结果:观察组治疗总有效率93.33%(22/30)高于对照组73.33%(28/30),P<0.05;治疗前,两组患者皮损程度评分差异无统计学意义(P>0.05),治疗后,观察组皮损程度评分(10.13±1.04)分明显低于对照组(15.41±2.18)分(P<0.05);治疗前,两组患者CTGF水平、TGF-β1水平差异无统计学意义(P>0.05),治疗后,观察组CTGF水平、TGF-β1水平明显低于对照组[(148.19±29.22)vs.(191.96±43.20)、(7.08±1.51)vs(12.01±2.86),P<0.05]。治疗后观察组患者脉沉迟、舌质胖、自觉乏力、畏寒肢冷、腹胀纳呆、皮损变硬萎缩评分明显低于对照组患者(P<0.05)。结论:火针治疗局限性硬皮病的疗效确切,皮损明显改善,降低了患者CTGF、TGF-β1水平,可以考虑积极推广。Objective:To compare the clinical efficacy of fire acupuncture and Bozhi(薄芝)glycopeptide injection in the treatment of localized scleroderma.Methods:60 patients with localized scleroderma treated in the Second Affiliated Hospital of Baotou Medical College from January 2018 to December 2019 were randomly divided into the control group(30 cases)and the observation group(30 cases).The patients in control group were treated with Bozhi glycopeptide injection,and the patients in the observation group were treated with fire acupuncture.The treatment efficiency,CTGF level,TGF-β1 level before and after treatment,TCM symptom score and skin lesions were compared between the two groups.Results:The total effective rate of treatment in the observation group was 93.33%(22/30),which was higher than that in control group,73.33%(28/30)(P>0.05).After treatment,the degree of skin lesions in the observation group(10.13±1.04)was significantly lower than that of the control group(15.41±2.18)(P<0.05).Before treatment,there was no significant difference in CTGF level and TGF-β1 level between the two groups of patients(P>0.05).The CTGF and TGF-β1 levels in the observation group were significantly lower than those in the control group after treatment[(148.19±29.22)vs(191.96±43.20),(7.08±1.51)vs(12.01±2.86),P<0.05].After treatment,the scores of pulse sinking late,tongue fat,self-conscious fatigue,cold limbs,abdominal distention and dullness,hardened and atrophy in the observation group were significantly lower than those in the control group(P<0.05).Conclusion:The curative effect of fire acupuncture in the treatment of localized scleroderma is accurate,the skin lesions are obviously improved,the level of CTGF and TGF-β1 is reduced,and it is worthy of positive promotion.

关 键 词：火针 薄芝糖肽注射液 局限性硬皮病 疗效 

分 类 号：R593.25[医药卫生—内科学]