静脉丙种球蛋白致婴幼儿产生IgG类抗体及交叉配血不合6例  

Crossmatch incompatibility in infants caused by intravenous immunoglobulin-produced IgG antibody:Six cases

作　　者：金晓红[1] 屈柯暄 陈蕊 周蓉[1] 王新 吕孟兴[1] JIN Xiaohong;QU Kexuan;CHEN Rui;ZHOU Rong;WANG Xin;LV Mengxing(Department of Blood Transfusion,Kunming Children's Hospital,Kunming 650228,China)

机构地区：[1]昆明市儿童医院输血科,云南昆明650228

出　　处：《中国输血杂志》2021年第7期776-778,共3页Chinese Journal of Blood Transfusion

基　　金：昆明市卫生科技人才培养项目暨“十百千”工程(项目编号:2021-SW(省)-024);不同剂量血浆或放散液在新生儿溶血病确诊试验中的研究(项目编号:2017-1-S-14363)。

摘　　要：目的分析输注静脉丙种球蛋白致新生儿产生IgG类抗体及对交叉配血不合的影响。方法应用微柱凝胶技术检测血型、抗体筛选、交叉配血、直接抗人球蛋白试验、放散及游离试验、静脉丙种球蛋白效价测定。结果 6例患儿放散及游离液中均检测出IgG类抗-A,IVIG中含有的IgG类抗-A效价达到256,产生的IgG类抗-A导致患儿与同型交叉配血均不相合。结论 IVIG可引起母婴ABO血型相同的新生儿产生IgG类抗体,从而导致溶血;同时还可引起交叉配血不合,输血时应选择O型洗涤红细胞输注。Objective To analyze the effect of intravenous immunoglobulin(IVIG)-produced IgG antibody on the crossmatch incompatibility of neonates.Methods Blood type grouping,antibody screening,crossmatch,direct anti-globulin test,elution test,indirect antiglobulin test,and IVIG titer determination were conducted by microcolumn gel method.Results IgG anti-A were detected out in the elution test and free antibody test of 6 infants,and the titer of IgG anti-A contained in IVIG was 256,which led to the crossmatch incompatibility between infants and donors with the same type.Conclusion The hemolysis and crossmatch incompatibility in newborns,born to ABO-compatible mothers,may occur due to the IVIG-induced IgG antibodies.The O-type washed red blood cells should be selected for transfusion.

关 键 词：静脉丙种球蛋白 新生儿溶血病 IgG类抗-A 交叉配血 

分 类 号：R457.11[医药卫生—治疗学] R174[医药卫生—临床医学]