微小RNA调控缺血再灌注心肌炎症的机制研究进展  

Mechanism of microRNAs regulating inflammation in myocardial ischemia-reperfusion injury

作　　者：杨富瑜 周涛 Yang Fuyu;Zhou Tao(Zunyi Medical University,Zunyi 563000,China;Department of Cardiac Surgery,Guizhou Provincial People's Hospital,Guiyang 550002,China)

机构地区：[1]遵义医科大学,563000 [2]贵州省人民医院心外科,贵阳550002

出　　处：《中华实验外科杂志》2021年第8期1610-1613,共4页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金(81960050);贵州省人民医院2019年度国家自然科学基金后补助基金(GPPH-NSFC-2019-24);贵州省科技计划项目(黔科合基础[2019]1204号)。

摘　　要：微小RNA(miRNAs)是一类小的非编码核糖核酸,可通过与下游靶基因的结合调控靶基因表达,是心脏缺血再灌注损伤的重要调控分子。炎症通路的激活是心肌缺血再灌注损伤发生的重要机制之一。研究miRNAs在心肌缺血再灌注炎性反应中的调控机制是揭示心肌缺血再灌注损伤机制的新思路。本文就miRNAs调控心肌缺血再灌注心肌炎症的机制研究进展作一综述。MicroRNAs(miRNAs)are a class of small noncoding RNAs that transcribe or regulate the expression of their target genes after transcriptional regulation,and have been identified as key regulatory molecules in many cardiovascular diseases including myocardial ischemia reperfusion injury(MIRI).The pathogenesis of MIRI is very complex,and inflammation has been widely accepted in the pathogenesis.It is of great significance to study the role of miRNAs in the inflammatory response of MIRI,which indicates a new idea for miRNAs to improve the inflammatory response of MIRI.This paper reviews the research progress of miRNAs in the inflammatory response of MIRI.

关 键 词：心肌缺血再灌注 微小RNA 炎症 

分 类 号：R542.21[医药卫生—心血管疾病]