2015年郑州地区人类乳头瘤病毒流行及基因型分布特征分析  

Prevalence and Genotype Distribution of Human Papillomavirus in Women in Zhengzhou,China,in 2015

作　　者：刘金瑾 马淑焕[1] 秦川[1] 郑遂玲 王平平[1] 霍玉奇[1] LIU Jinjin;MA Shuhuan;QIN Chuan;ZHENG Suiling;WANG Pingping;HUO Yuqi(The Sixth People's Hospital of Zhengzhou,Zhengzhou 450000,China)

机构地区：[1]郑州市第六人民医院,郑州450000

出　　处：《病毒学报》2021年第4期824-830,共7页Chinese Journal of Virology

摘　　要：收集2015年郑州市15个地区25~64岁之间的女性宫颈脱落细胞样本50050份。采用荧光定量PCR方法对样本进行HPV-DNA检测,进一步进行23种基因分型。检测结果采用logistic回归,对不同年龄段感染差异情况进行比较。检出总阳性率9.38%(4696/50050),检出率最高的五种型别分别是HPV52型、16型、58型、53型和51型。单一感染在所有感染中占比67.65%(3177/4696),多重感染占比32.35%(1519/4696);高危型别感染占比94.66%(4445/4696),低危型别感染占比5.34%(251/4696)。HPV感染率随年龄增加而增加,55~64岁感染率最高,达10.98%(659/6001)。单一感染在各个年龄段中感染率差异不大。多重感染随年龄增加而增加,25~34岁感染率最低(2.65%,54/2041),55~64岁感染率最高(4.60%,276/6001)。九价HPV宫颈癌疫苗以外HPV高危型别感染率为3.09%(1545/50050)。结果表明2015年郑州地区HPV感染率前五位的型别分别是HPV52型、HPV16型、HPV58型、HPV53型和HPV51型。HPV总感染率随年龄的增加而增加,年龄增加是发生HPV多重感染的风险因素。目前市场上推广使用的九价HPV宫颈癌疫苗不能为约32.90%(1545/4696)的高危感染者提供保护。对郑州地区女性人类乳头瘤病毒(Human papillomavirus,HPV)流行情况及基因型分布特征进行探讨研究,可以为制定预防控制策略提供数据支持。We wished to explore the prevalence and genotype distribution of human papillomaviruses(HPVs)among women in Zhengzhou,China,in 2015.Cervical epithelial cells were collected from 50050 women aged 25 to 64 years in 15 districts of Zhengzhou in 2015.The presence and 23 genotypes of HPV⁃DNA in samples were determined sequentially by fluorescence real⁃time polymerase chain reaction(PCR)assay.Logistic regression models were used to compare differences of infection in different age groups.HPV⁃DNA was detected in 4696 cases,giving a total positive prevalence of 9.38%(4696/50050).The five most commonly detected genotypes were HPV52,HPV16,HPV58,HPV53,and HPV51.Single and multiple infections accounted for 67.65%(3177/4696)and 32.35%(1519/4696)respectively.While high⁃risk HPV and low⁃risk HPV infections accounted for 94.66%(4445/4696)and 5.34%(251/4696)respectively.The prevalence of HPV infection increased with age and was highest in those aged 54~64 years(10.98%,659/6001).There were no significant differences of single infections in different age groups.The prevalence of multiple infections increased with age and was lowest in those aged 25~34 years(2.65%,54/2041),and highest in those 55~64 years(4.60%,276/6001).The percentage of high⁃risk HPV infections not covered by the nonavalent vaccine was 3.09%(1545/50050).The five most commonly found genotypes in Zhengzhou in 2015,China were HPV52,HPV16,HPV58,HPV53,and HPV51.The prevalence of HPV infection increased with age,and increased age was a risk factor for multiple infections.Approximately 32.90%(high⁃risk HPV infection)of total infections could not be fully protected by the current nonavalent HPV cervical cancer vaccine.Our study provides valuable data to aid the Chinese government’s decision⁃making in developing prevention and control strategies against HPV infection.

关 键 词：人类乳头瘤病毒 宫颈癌 流行 基因型分布 

分 类 号：R373.9[医药卫生—病原生物学]