心肺运动试验应用于系统性硬化病相关肺动脉高压筛查的研究进展  

Cardiopulmonary Exercise Test for Screening of Systemic Sclerosis-Associated Pulmonary Hypertension

作　　者：张毅[1] 罗勤[1] 赵智慧[1] 赵青[1] 柳志红[1] ZHANG Yi;LUO Qin;ZHAO Zhihui;ZHAO Qing;LIU Zhihong(Fuwai Hospital,National Center for Cardiovascular Disease,Chinese Academy of Medical Science and Peking Union Medical College,Beijing 100037,China)

机构地区：[1]中国医学科学院北京协和医学院国家心血管病中心阜外医院,北京100037

出　　处：《心血管病学进展》2021年第7期577-581,589,共6页Advances in Cardiovascular Diseases

基　　金：首都临床特色应用研究(Z181100001718200);北京市自然科学基金(7202168)。

摘　　要：肺动脉高压是结缔组织病的严重并发症之一,其中以系统性硬化病相关肺动脉高压和系统性红斑狼疮相关肺动脉高压最为常见。因早期症状不明显,大多数系统性硬化病相关肺动脉高压直至出现严重的临床症状,以及功能状态严重受损时才被确诊。虽然目前有一些有效的筛查手段,但它们在适用人群、特异度和阴性预测值等方面尚不能令人满意。心肺运动试验是评估患者运动耐量的金标准。通过比较合并与不合并肺动脉高压的系统性硬化病患者,在运动负荷状态下心肺功能的差异,或许能为系统性硬化病相关肺动脉高压的筛查开拓出新的道路。现就近年来心肺运动试验应用于系统性硬化病相关肺动脉高压筛查的研究进展做一综述。Pulmonary hypertension is one of the serious complications of connective tissue.Systemic sclerosis-associated pulmonary arterial hypertension and systemic lupus erythematosus-associated pulmonary arterial hypertension are the most common.Most individuals present with severe symptoms and significant functional impairment at diagnosis,because they tend to be asymptomatic at early stage.Although there are some effective screening methods,they are not satisfactory in terms of applicable population,specificity and negative predictive value.Cardiopulmonary exercise test is the gold standard for the assessment of exercise capacity.By comparing the difference of cardiopulmonary function between patients with and without pulmonary hypertension under exercise load,it may open up a new way for the screening of systemic sclerosis-associated pulmonary arterial hypertension.This article reviews the research progress of cardiopulmonary exercise test in screening systemic sclerosis-associated pulmonary arterial hypertension in recent years.

关 键 词：心肺运动试验 系统性硬化病 肺动脉高压 筛查 

分 类 号：R54[医药卫生—心血管疾病]