治疗高血压的新靶点:血管紧张素原  

A New Target for Treatment of Hypertension:Angiotensinogen

作　　者：王咏春 高红梅[2,3] 刘芳[2] 朱希瑶 徐茂青 WANG Yongchun;GAO Hongmei;LIU Fang;ZHU Xiyao;XU Maoqing(Shandong University of Traditional Chinese Medicine,Jinan 250000,Shandong,China;Department of Cardiology,The Second Affiliated Hospital,Shandong University of Traditional Chinese Medicine,Jinan 250000,Shandong,China;Postdoctoral Mobile Station of Shandong University of Traditional Chinese Medicine,Jinan 250000,Shandong,China)

机构地区：[1]山东中医药大学,山东济南250000 [2]山东中医药大学第二附属医院心内科,山东济南250000 [3]山东中医药大学博士后流动站,山东济南250000

出　　处：《心血管病学进展》2021年第7期619-624,共6页Advances in Cardiovascular Diseases

基　　金：山东省中医药科技发展计划(2019-0241);山东省医药卫生科技发展计划(2019WS560)。

摘　　要：高血压是全球患病率最高的非感染性慢性病,也是许多心血管疾病共有的危险因素。大多数高血压病例不可治愈,终生服药给社会和患者带来沉重负担。肾素-血管紧张素系统在高血压、冠心病和心力衰竭等心血管疾病的发生和发展中扮演着重要角色,其中血管紧张素原是肾素-血管紧张素系统的上游分子,近年来的研究表明血管紧张素原有望成为治疗高血压的理想靶点。RNA干扰技术是前景良好的基因沉默技术,具有精确地调控基因表达的潜力,将其用于靶向致病基因具有重要的临床意义。现汇总近年来血管紧张素原与高血压的有关研究,简要概述RNA干扰的原理,以及靶向血管紧张素原基因的小干扰RNA用于降压治疗的进展。Hypertension is a non infectious chronic disease with the highest prevalence rate in the world.It is also a common risk factor for many cardiovascular diseases.Most of hypertension is incurable and life-long medication,and brings heavy burden to society and patients.Renin-angiotensin system plays an important role in the occurrence and development of cardiovascular diseases such as hypertension,coronary heart disease,heart failure and so on.Among them,angiotensinogen is the upstream molecule of renin-angiotensin system.Recent studies have shown that angiotensinogen is expected to become an ideal target for the treatment of hypertension.RNA interference is a promising gene silencing technology,which has the potential to precisely regulate gene expression.It has important clinical significance to target pathogenic genes.In this paper,we summarize the recent studies on angiotensinogen and hypertension,and summarize the principle of RNA interference and the progress of small interfering RNA targeting angiotensinogen gene in antihypertensive therapy.

关 键 词：血管紧张素原 RNA干扰 小干扰RNA 肾素-血管紧张素系统阻断剂 

分 类 号：R54[医药卫生—心血管疾病]