闭环神经信号记录和可调节双模电刺激系统  

Closed-loop neural signal recording and adjustable dual-mode electrical stimulation system

作　　者：谭文硕 赵明[3] 尹韬 尤昌华 刘春秀 薛宁 TAN Wenshuo;ZHAO Ming;YIN Tao;YOU Changhua;LIU Chunxiu;XUE Ning(State Key Laboratory of Transducer Technology,Aerospace Information Research Institute,Chinese Academy of Sciences,Beijing 100190,China;School of Electronic,Electrical,and Communication Engineering,University of Chinese Academy of Sciences(UCAS),Beijing 100190,China;Department of Neurosurgery,Fourth Medical Center,Chinese PLA General Hospital,Beijing 100048,China)

机构地区：[1]中国科学院空天信息创新研究院传感器技术国家重点实验室,北京100190 [2]中国科学院大学电子电气与通信工程学院,北京100190 [3]中国人民解放军总医院第四医疗中心神经外科,北京100048

出　　处：《传感器与微系统》2021年第8期73-75,78,共4页Transducer and Microsystem Technologies

基　　金：国家重点研发计划资助项目(2019YFC200028);国家自然科学基金资助项目(61774157,81771388,61802363);北京自然科学基金资助项目(4182075)。

摘　　要：为了治疗帕金森病,提出了一种神经电信号记录和可调节电刺激闭环同步控制系统。系统的前端采集模块,用于采集神经信号;微处理器作为控制系统,并能根据异常信号生成电刺激脉冲;以及双模式(恒压和恒流)可调节电刺激电路。设计的系统本底噪声小于8μV(RMS),能够测量出20μV的正弦信号和200μV以下的模拟神经信号。输出的可调电刺激脉冲的电压幅度范围为0~3.3 V或电流为0~1 mA,频率为0~1 kHz且最小脉冲宽度为1μs。A nerve electrical signal recording and self-adjustable stimulation closed-loop system for Parkinson's disease is proposed.The system consists of front-end acquisition module,which acquire neural signal;microprocessor is used as control system and can generate electrical stimulation pulses according to abnormal signal,and dual mode(constant voltage and constant current)stimulation circuit for self-adjustable electrical pulses stimulation.The system has the noise floor within 8μV(RMS).Sinusoidal signals 20μV and simulated neural signal below 200μV are measured.The voltage amplitude of output adjustable electrical stimulation pulses are in the range of 0~3.3 V or current of 0~1 mA,frequency of 0~1 kHz and the minimum pulse width of 1μs.

关 键 词：闭环系统 电子医学 神经电刺激 

分 类 号：TM935[电气工程—电力电子与电力传动] TP212[自动化与计算机技术—检测技术与自动化装置]