非ST段抬高型急性冠脉综合征患者C反应蛋白与白蛋白比值与冠状动脉病变严重程度的关系  

Relationship Between C-Reactive Protein to Albumin Ratio and Severity of Coronary Artery Disease in Patients with Non-ST Segment Elevation Acute Coronary Syndrome

作　　者：姚芳 张强[1] 杨丽红[2] 孙彩红[1] 刘方方 信彩凤 YAO Fang;ZHANG Qiang;YANG Lihong;SUN Caihong;LIU Fangfang;XIN Caifeng(Department of Cardiology,the Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450014,China;Department of Cardiopulmonary Function,Henan Province People’s Hospital,Zhengzhou 450003,China)

机构地区：[1]郑州大学第二附属医院心内科,河南郑州450014 [2]河南省人民医院心肺功能科,河南郑州450003

出　　处：《河南医学研究》2021年第19期3476-3479,共4页Henan Medical Research

基　　金：河南省科技攻关项目(182102310509)

摘　　要：目的探讨非ST段抬高型急性冠脉综合征(NSTE-ACS)患者C反应蛋白与白蛋白比值(CAR)与冠状动脉病变严重程度的关系。方法选取2018—2020年于郑州大学第二附属医院接受冠状动脉造影的154例NSTE-ACS患者,根据SYNTAX评分,将患者分为轻度病变组(98例,SYNTAX评分<23分)和中重度病变组(56例,SYNTAX评分≥23分)。比较两组临床资料,采用多因素logistic回归分析NSTE-ACS患者冠状动脉中重度病变的独立危险因素,采用受试者工作特征(ROC)曲线分析CAR对NSTE-ACS患者冠状动脉中重度病变的预测价值。结果中重度病变组年龄、糖尿病比率、氨基末端B型利钠肽前体(NT-proBNP)、低密度脂蛋白胆固醇(LDL-C)、CAR均高于轻度病变组(P<0.05)。多因素logistic回归分析结果显示,CAR是NSTE-ACS患者冠状动脉病变严重程度的独立影响因素(P<0.05)。ROC曲线结果显示,CAR预测NSTE-ACS冠状动脉中重度病变的曲线下面积为0.787,预测临界值为18.02,敏感度为73.23%、特异度为74.28%。结论CAR是NSTE-ACS冠状动脉病变严重程度的独立影响因素,且CAR对NSTE-ACS患者冠状动脉病变严重程度具有一定的预测价值。Objective To explore the relationship between C-reactive protein to albumin ratio(CAR)and severity of coronary artery disease in patients with non-ST segment elevation acute coronary syndrome(NSTE-ACS).Methods A total of 154 patients with NSTE-ACS who underwent coronary angiography in the Second Affiliated Hospital of Zhengzhou University from 2018 to 2020 were selected.According to SYNTAX score,they were divided into mild disease group(98 cases)with SYNTAX score<23 and moderate and severe disease group(56 cases)with SYNTAX score≥23.The clinical data of the two groups were compared.The independent risk factors of moderate and severe coronary artery lesions in patients with NSTE-ACS were analyzed by multivariate logistic regression,and the predictive value of CAR for moderate and severe coronary artery lesions in patients with NSTE-ACS was analyzed according to the receiver operating characteristic(ROC)curve.Results The age,ratio of diabetes history,N-terminal pro-B-type natriuretic peptide(NT-proBNP),low density lipoprotein-cholesterol(LDL-C)and CAR in moderate and severe disease group were all higher than those in mild disease group(P<0.05).Multivariate logistic regression analysis showed that CAR was an independent factor affecting the severity of coronary artery disease in NSTE-ACS(P<0.05).The results of ROC curve showed that the area under the curve of CAR predicting moderate and severe coronary artery lesions in NSTE-ACS was 0.787.The predictive critical value was 18.02,and the predictive sensitivity was 73.23%,and the specificity was 74.28%.Conclusion CAR is an independent factor affecting the severity of coronary artery disease in NSTE-ACS,and it has a certain value in predicting the severity of coronary artery disease in patients with NSTE-ACS.

关 键 词：非ST段抬高型急性冠脉综合征 C反应蛋白与白蛋白比值 冠状动脉病变 

分 类 号：R542.2[医药卫生—心血管疾病]