细毡毛忍冬花蕾中1个新六降三萜成分  

A novel hexanor⁃triterpenoid from the buds of Lonicera similis

作　　者：卜兰 熊亮[1,2] 刘菲 张潇 蒙春旺[1,2] 郭力 BU Lan;XIONG Liang;LIU Fei;ZHANG Xiao;MENG Chun-wang;GUO Li(Pharmacy College,Chengdu University of TCM,The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine,Chengdu 611137,China;Institute of Innovative Medicine Ingredients of Southwest Specialty Medicinal Materials,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China)

机构地区：[1]成都中医药大学药学院,教育部中药材标准化重点实验室,四川成都611137 [2]西南特色药材创新药物成分研究所,四川成都611137

出　　处：《中成药》2021年第8期2105-2108,共4页Chinese Traditional Patent Medicine

基　　金：四川省青年科技创新研究团队专项计划项目(2017TD0001);四川高校科研创新团队建设计划(18TD0017)。

摘　　要：目的研究细毡毛忍冬Lonicera similis Hemsl.干燥花蕾的化学成分。方法细毡毛忍冬干燥花蕾70%乙醇提取物的分析采用硅胶柱、Sephadex LH⁃20、MCI、HPLC进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到一个新的六降三萜,鉴定为3β,20⁃二羟基⁃22,23,24,25,26,27⁃六降羊毛脂烷⁃8⁃烯⁃11⁃氧代⁃29⁃酸(1)。结论化合物1为从该植物中分离得到的一个新的罕见六降羊毛脂烷三萜。AIM To study the chemical constituents from the dry buds of Lonicera similis Hemsl.METHODS The 70%ethanol extract from the dry buds of L.similis was isolated and purified by silica column,Sephadex LH⁃20,MCI,and HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS A novel hexanor⁃triterpenoid was isolated and identified as 3β,20⁃dihydroxy⁃22,23,24,25,26,27⁃hexanorlanosta⁃8⁃en⁃11⁃oxo⁃29⁃oic acid(1).CONCLUSION Compound 1 is a novel and rare hexanorlanostane⁃triterpenoid isolated from this plant.

关 键 词：细毡毛忍冬 花蕾 六降三萜 化学成分 分离鉴定 

分 类 号：R284.1􀆰[医药卫生—中药学]