原发性高血压患者经典瞬时受体电位通道1基因多态性与左心室肥厚的关系  

Correlation between classical transient receptor potential channel 1 gene polymorphism and left ventric⁃ular hypertrophy in patients with primary hypertension

作　　者：曹亚萍 张宇[1] 陈玉岚[1] 张向阳[1] 李瑜[2] 徐新娟[1] CAO Yaping;ZHANG Yu;CHEN Yulan;ZHANG Xiangyang;LI Yu;XU Xinjuan(Department of Hypertension,the First Teaching Hospital of Xinjiang Medical University,Urumqi 830011,China;不详)

机构地区：[1]新疆医科大学第一附属医院高血压科,乌鲁木齐830011 [2]新疆医科大学第一附属医院综合内二科

出　　处：《山东医药》2021年第23期1-5,共5页Shandong Medical Journal

基　　金：国家自然科学基金资助项目(82060058)。

摘　　要：目的观察原发性高血压患者经典瞬时受体电位通道1(TRPC1)基因多态性改变,并分析其与患者并发左心室肥厚(LVH)的关系。方法选取原发性高血压患者438例,根据超声心动图测量的左心室质量指数将患者分为LVH组73例、对照组365例。采用Sequenom MassARRAY■ SNP技术检测两组外周血TRPC1基因Rs13086677、Rs3821647、Rs7638459、Rs953239、Rs7621642位点的多态性,比较两组各位点基因型、等位基因、显性模型、隐性模型、相加模型的频率分布情况,并对有差异的基因多态性相关因素进行多因素Logistic回归分析。结果 TRPC1各位点的基因频率分布均符合Hardy-Weinberg平衡定律(P均>0.05),研究对象具有群体代表性。LVH组Rs7638459位点CC基因型频率高于对照组,隐性模型中的CC基因型频率高于对照组(P均<0.05);两组其他位点基因型、等位基因及各模型频率分布比较差异均无统计学意义(P均>0.05)。多因素Logistic回归分析结果显示,Rs7638459位点CC基因型频率升高是原发性高血压患者发生LVH的独立危险因素(P<0.05)。结论TRPC1基因Rs7638459位点基因多态性与原发性高血压患者发生LVH有关,其中CC基因型患者更易发生LVH。Objective To observe the changes in classical transient receptor potential channel 1(TRPC1)gene polymorphisms in patients with primary hypertension,and to analyze their relationship with left ventricular hypertrophy(LVH).Methods A total of 438 patients with primary hypertension were selected and were divided into the LVH group(73 cases)and control group(365 cases)according to the results of left ventricular mass index measured by echocardiogra-phy.The Sequenom MassARRAY®SNP technology was used to detect the polymorphisms of Rs13086677,Rs3821647,Rs7638459,Rs953239,and Rs7621642 of TRPC1 gene in the peripheral blood of two groups.We compared genotypes CC,CT,TT,C,T alleles,the frequency distribution of CC,CT+TT dominant model,TT,CT+CC recessive model,CT,CC+TT additive model,etc.of the two groups,and multivariate Logistic regression analysis was performed on the related factors of different gene polymorphisms.Results The gene frequency distribution at each site of TRPC1 conformed to the Hardy-Weinberg equilibrium law(P>0.05),and the research objects were representative.The frequency of CC genotype at Rs7638459 in the LVH group was higher than in the control group,and the frequency of CC genotype in the reces-sive model was also higher than in the control group(P<0.05);there was no statistically significant difference between the two groups in the genotypes of other loci and the distribution of each model(all P>0.05).Multivariate Logistic regression analysis showed that the increased frequency of CC genotype at Rs7638459 was an independent risk factor for LVH in pa-tients with primary hypertension(P<0.05).Conclusion The genetic polymorphism at Rs7638459 of TRPC1 gene is associated with LVH in patients with hypertension,and LVH is more likely to occur in patients with CC genotype.

关 键 词：经典瞬时受体电位通道1 单核苷酸多态性 左心室肥厚 原发性高血压 CC基因型 

分 类 号：R544.1[医药卫生—心血管疾病]