甘精胰岛素、格列美脲、阿卡波糖片联合用于继发性磺脲类失效的2型糖尿病患者的临床效果分析  

Clinical effect analysis of insulin glargine,glimepiride,and acarbose tablets on type 2 diabetes patients with secondary sulfonylurea failure

作　　者：岳萃涛 YUE Cui-tao(Department of general medicine,the First Affiliated Hospital of University of science and technology of China,Hefei Anhui 230601,China)

机构地区：[1]中国科学技术大学附属第一医院全科医学科,合肥230601

出　　处：《中国处方药》2021年第8期120-122,共3页Journal of China Prescription Drug

基　　金：安徽省自然科学基金项目(1708095E073);2018年国家自然科学基金资助项目(81870192)。

摘　　要：目的观察甘精胰岛素、格列美脲、阿卡波糖片联合用于继发性磺脲类失效的2型糖尿病(T2DM)患者的临床效果。方法抽取2017年8月~2020年8月间接受治疗的继发性磺脲类失效T2DM患者118例作为研究对象,按照随机数字表法分为A、B、C三组,其中A组39例患者给予甘精胰岛素+格列美脲治疗,B组39例患者给予甘精胰岛素+阿卡波糖片治疗,C组40例患者给予甘精胰岛素+格列美脲+阿卡波糖片治疗,比较三组治疗前后血糖水平变化、胰岛功能变化及治疗后血糖达标情况与药物不良反应发生情况。结果治疗后,三组HbA1c、FBG、2hPG血糖指标水平与FINS、2h FINS、HOMA-IR、HOMA-β胰岛功能指标水平均改善(P<0.05),且C组改善程度优于A组与B组(P<0.05);C组患者24 h胰岛素用量、24 h血糖达标维持时间及低血糖发生率均优于A组与B组(P<0.05)。结论给予T2DM患者甘精胰岛素、格列美脲、阿卡波糖片三药联合应用,可使血糖水平得到有效控制,安全可靠。Objective To observe the clinical effect of insulin glargine,glimepiride,and acarbose tablets on type 2 diabetes patients with secondary sulfonylurea failure.Methods 118 T2DM patients with secondary sulfonylurea failure treated in our hospital from August 2017 to August 2020 were selected as the research objects,and divided into three groups A,B,and C according to the random number table method.39 patients in group A were treated with insulin glargine and glimepiride,39 patients in group B were treated with insulin glargine and acarbose tablets,and 40 patients in group C were treated with insulin glargine,glimepiride and acarbose tablets.The changes in blood glucose levels,changes in pancreatic islet function before and after treatment in the three groups were compared,and the blood glucose standards after treatment and the occurrence of adverse drug reactions were compared.Results After treatment,the three groups of HbA1C,FBG,2hPG and FINS,2h FINS,HOMA-IR,HOMA-βislet function index levels improved(P<0.05),and the improvement of group C was better than that of group A and B Group(P<0.05);24h insulin dosage,24h blood glucose maintenance time and incidence of hypoglycemia were better than those in group A and B(P<0.05).Conclusion The combined application of insulin glargine,glimepiride,and acarbose tablets in T2DM patients with secondary sulfonylurea failure can effectively control blood glucose levels,which is safe and reliable.

关 键 词：甘精胰岛素 格列美脲 阿卡波糖片 继发性磺脲类失效T2DM 

分 类 号：R587.1[医药卫生—内分泌]