杀伤细胞免疫球蛋白样受体和人白细胞抗原C基因型特定前葡萄膜炎的关系  

Associations of killer cell immunoglobulin-like receptors and human leukocyte antigens C with certain anterior uveitis

作　　者：王玉青 刘云霞[2] 任桂芳[2] WANG Yu-Qing;LIU Yun-Xia;REN Gui-Fang(Binzhou Central Blood Station,Binzhou 256613,China)

机构地区：[1]滨州市中心血站,滨州256613 [2]济南市第四人民医院,济南250031

出　　处：《中国免疫学杂志》2021年第13期1628-1632,共5页Chinese Journal of Immunology

摘　　要：目的:探讨杀伤细胞免疫球蛋白样受体(KIRs)和人类白细胞抗原C(HLA-C)与HLA-B27相关的急性前葡萄膜炎(B27AAU)和特发性AAU(IAAU)的关系。方法:应用序列特异性引物聚合酶链反应对196例B27AAV和IAAU患者和210例正常人进行KIR基因和HLA-C等位基因分析。结果:B27AAU组的HLA-C2和KIR2DL1/HLA-C2的频率分别为0.009和0.044,而HLA-C1C1和HLA-C1的频率较低(P=0.034和P=0.009)。在IAAU中,KIR2DL2和KIR2DL2/HLA-C1的频率高于对照组(P=0.009和P=0.044),而KIR2DL3和KIR2DL3/HLA-C1的频率较低(分别为P=0.000和P=0.001)。结论:HLA-C2和KIR2DL1/HLAC2、KIR2DL2和KIR2DL2/HLA-C1可能分别对B27AAU和IAAU敏感。HLA-C1C1和HLA-C1、KIR2DL3和KIR2DL3/HLA-C1可能分别对B27AAU和IAAU起保护作用。Objective:To investigate the associations of the killer cell immunoglobulin-like receptors(KIRs)and human leukocyte antigens C(HLA-C)with the HLA-B27 associated acute anterior uveitis(B27 AAU)and idiopathic AAU(IAAU).Methods:Polymerase chain reaction with sequence-specific primers was used to analyze KIR genes and HLA-C alleles.In a Chinese Han population of 196 B27 AAU and IAAU patients and 210 control subjects.Results:The frequencies of HLA-C2 and KIR2 DL1/HLA-C2 in B27 AAU group were 0.009 and 0.044,respectively,while the frequencies of HLA-C1 C1 and HLA-C1 in B27 AAU group were lower(P=0.034 and P=0.009).In IAAU group,the frequencies of KIR2 DL2 and KIR2 DL2/HLA-C1 were higher than those in control group(P=0.009 and P=0.044),while the frequencies of KIR2 DL3 and KIR2 DL3/HLA-C1 were lower(P=0.000 and P=0.001,respectively).Conclusion:HLA-C2 and KIR2 DL1/HLA-C2,KIR2 DL2 and KIR2 DL2/HLA-C1 may be sensitive to B27 AAU and IAAU respectively.HLA-C1 C1 and HLA-C1,KIR2 DL3 and KIR2 DL3/HLA-C1 may play roles in protecting from B27 AAU and IAAU.

关 键 词：杀伤细胞免疫球蛋白样受体 人白细胞抗原C 基因型 急性前葡萄膜炎 

分 类 号：R392.12[医药卫生—免疫学]