血清PCT、D-D、NT-proBNP及白细胞水平对社区获得性肺炎患者的临床意义  

Clinical Significance of Serum PCT,D-D,NT-proBNP and Leukocyte Levels in Patients with Community-acquired Pneumonia

作　　者：刘颜岗[1] 索文莉 王倩 李艳静[4] 李站领[1] 常占平[4] LIU Yangang;SUO Wenli;WANG Qian;LI Yanjing;LI Zhanling;CHANG Zhanping(Department of Respiratory,Qinhuangdao Third Hospital,Qinhuangdao 066000,China;Army Military Transportation University Foundation Division,Tianjin 300000,China;Department of Orthopaedics,Lulong County Hospital,Qinhuangdao,Qinhuangdao 066000,China;Department of Pulmonary Diseases,Qinhuangdao Third Hospital,Qinhuangdao 066000,China)

机构地区：[1]秦皇岛市第三医院呼吸科,秦皇岛066000 [2]陆军军事交通学院基础部,天津300000 [3]秦皇岛市卢龙县医院骨科,秦皇岛066000 [4]秦皇岛市第三医院肺病科,秦皇岛066000

出　　处：《宁夏医科大学学报》2021年第7期677-681,共5页Journal of Ningxia Medical University

基　　金：秦皇岛市科技支撑项目(201602A183)。

摘　　要：目的探讨血清降钙素原(procalcitonin,PCT)、D-二聚体(D-dimer,D-D)、N末端脑钠肽前体(N-terminal pro-brain natriuretic peptide,NT-proBNP)及白细胞水平对社区获得性肺炎(community-acquired pneumonia,CAP)病情评估的意义。方法选取2016年1月至2018年7月在秦皇岛市第三医院呼吸科住院的130例CAP患者,根据病情严重程度分为重症肺炎组(n=25)和非重症肺炎组(n=105);另根据感染病原体将非重症肺炎组分为细菌性肺炎组(n=42)、支原体肺炎组(n=25)和病毒性肺炎组(n=38)。根据患者入院后28 d内存活情况分为存活组(n=113)和死亡组(n=17)。对照组选取同期50例健康体检者。比较不同组别患者的血清PCT、D-D、NT-proBNP、白细胞水平。结果支原体肺炎组患者的年龄低于细菌性肺炎组和病毒性肺炎组(P均<0.05)。细菌性肺炎组患者的血清PCT、D-D、NT-proBNP及白细胞水平均高于支原体肺炎组和病毒性肺炎组(P均<0.05),支原体肺炎组和病毒性肺炎组患者各指标水平相当(P均>0.05)。重症肺炎组患者血清PCT、D-D、NT-proBNP及白细胞水平均高于非重症肺炎组和对照组(P均<0.05),且非重症肺炎组高于对照组(P均<0.05)。死亡组患者的血清PCT、D-D、NT-proBNP及白细胞水平均高于存活组(P均<0.05)。结论血清PCT、D-D、NT-proBNP及白细胞水平在CAP患者中呈高表达,且重症感染及死亡患者其表达更高,检测PCT、D-D、NT-proBNP及白细胞水平有助于评估CAP患者病情。Objective To investigate the significance of serum procalcitonin(PCT),D-dimer(D-D),N-terminal pro-brain natriuretic peptide(NT-proBNP)and white blood cell levels in the assessment of community-acquired pneumonia(CAP).Methods A total of 130 patients with CAP admitted to the respiratory department of Qinhuangdao Third Hospital from January 2016 to July 2018 were selected as the research objects.They were divided into severe pneumonia group(n=25)and non-severe pneumonia group(n=105)according to the severity of the disease.According to different infectious pathogens,the non-severe pneumonia group was divided into bacterial pneumonia group(n=42),mycoplasma pneumonia group(n=25)and viral pneumonia group(n=38),the patients were divided into survival group(n=113)and death group(n=17)according to their survival within 28 d after admission.Fifty healthy subjects were included in the control group during the same period.The levels of serum PCT,D-D,NT-proBNP and white blood cells in different groups were compared.Results The average age of the mycoplasma pneumonia group was lower than that of the bacterial pneumonia group and the viral pneumonia group(P all<0.05).The serum PCT,D-D,NT-proBNP and white blood cells levels in the bacterial pneumonia group were higher than those in the mycoplasma pneumonia group and the viral pneumonia group(P all<0.05),while the levels of the mycoplasma pneumonia group and the viral pneumonia group were similar(P all>0.05).The serum PCT,D-D,NT-proBNP and white blood cell levels in the severe pneumonia group were higher than those in the non-severe pneumonia group and the control group(P all<0.05),and the non-severe pneumonia group were higher than the control group(P all<0.05).The serum PCT,D-D,NT-proBNP and white blood cell levels in the death group were higher those of the survival group(P all<0.05).Conclusion The levels of serum PCT,D-D,NT-proBNP and white blood cell were high in CAP patients and higher in patients with severe infection and death.The detection of PCT,D-D,NT-proBNP and white b

关 键 词：降钙素原 白细胞 D-二聚体 N末端脑钠肽前体 社区获得性肺炎 

分 类 号：R563.1[医药卫生—呼吸系统]