2006-2018年宁夏成人艾滋病患者抗病毒治疗后生存及其影响因素  

Analysis of the Survival Conditions of Adult HIV/AIDS Patients Receiving Antiretroviral Therapy and the Related Factors in Ningxia from 2006 to 2018

作　　者：赵立华[1] 靳峰[1] 张蕴慧 蒋岸[1] ZHAO Lihua;JIN Feng;ZHANG Yunhui;JIANG An(Ningxia Hui Autonomous Region Center for Disease Control and Prevention,Yinchuan 750004,China)

机构地区：[1]宁夏回族自治区疾病预防控制中心,银川750004

出　　处：《宁夏医科大学学报》2021年第7期725-728,共4页Journal of Ningxia Medical University

摘　　要：目的分析宁夏成人艾滋病患者抗病毒治疗后的生存情况及其影响因素。方法以宁夏2006—2018年入组参加抗病毒治疗的成人艾滋病病毒感染者(human immunodeficiency virus/acquired immunodeficiency syndrome,HIV/AIDS)为研究对象,定期随访,采用寿命表法计算研究对象的存活率,采用Cox比例风险回归模型分析研究对象生存时间的影响因素。结果共纳入研究对象1421例,因艾滋病相关死亡42例(3.0%),第1~4年的累计存活率为97.8%、97.1%、96.0%、94.6%。Cox比例风险回归模型分析显示,文化程度、传播途径、基线CD4^(+)T淋巴细胞计数水平、是否发生机会性感染是影响生存时间的因素(P均<0.05)。结论宁夏成人HIV/AIDS病例接受免费抗病毒治疗后存活率高,治疗效果好。影响艾滋病抗病毒治疗患者病死率的因素为文化程度、传播途径、基线CD4^(+)T淋巴细胞计数水平、有机会性感染发生。Objective To explore the survival and it's influencing factors among adult human immunodeficiency virus/acquired immunodeficiency syndrome(HIV/AIDS)patients of highly active antiretroviral therapy(HAART)program in Ningxia from 2006 to 2018.Methods A retrospective cohort study was conducted among HIV/AIDS patients who received antiretroviral therapy from 2006 to 2018.Survival data of patients were collected.Life table method was applied to calculate the survival proportion,Cox proportion hazard regression model was performed to identify the factors related to survival time.Results A total number of 1421 cases was selected and he total case fatality ratio was 3.0%and the 1 to 4 actuarial survival rates were 97.8%,97.1%,96.0%,94.6%after ART.Multivariate Cox regression showed the related factors were transmission route,degree of education,opportunistic infection,and the CD4^(+)T cell counts(P all<0.05).Conclusion The antiretroviral therapy resulted in low fatality rate and high survival rate among HIV/AIDS patients and was significantly effective in Ningxia.The related factors were transmission route,degree of education,opportunistic infection,the CD4^(+)T cell counts when antiretroviral therapy began.

关 键 词：艾滋病 抗病毒治疗 生存分析 宁夏 

分 类 号：R512.91[医药卫生—内科学]