基于辨状论质法结合熵权法分析辛夷外观性状与内在质量的相关性  

Correlation between The Appearance Characteristics and The Intrinsic Quality of Magnoliae Flos Based on Quality-discrimination-by-character Combined with Entropy-weight Method

作　　者：贾银芝 吴琦 王鑫 王永香[1,2,3] 章晨峰 王振中[1,2,3] 肖伟 JIA Yinzhi;WU Qi;WANG Xin;WANG Yongxiang;ZHANG Chenfeng;WANG Zhenzhong;XIAO Wei(Jiangsu Kanion Pharmaceutical Co.,Ltd.,Lianyungang 222001 Jiangsu,China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process,Lianyungang 222001 Jiangsu,China;The Key Laboratory for the New Technique Research of TCM Extraction and Purification,Lianyungang 222001 Jiangsu,China;Lianyungang Food and Drug Inspection Center,Lianyungang 222001 Jiangsu,China)

机构地区：[1]江苏康缘药业股份有限公司,江苏连云港222001 [2]中药制药过程新技术国家重点实验室,江苏连云港222001 [3]中药提取精制新技术重点研究室,江苏连云港222001 [4]连云港市食品药品检验检测中心,江苏连云港222006

出　　处：《中药新药与临床药理》2021年第8期1178-1182,共5页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：国家重大新药创制科技重大专项(2013ZX09402203)。

摘　　要：目的基于辨状论质法结合熵权法,分析辛夷外观性状与内在质量的相关性,为辛夷的等级划分提供依据。方法测定21批辛夷药材挥发油含量、木兰脂素含量、花蕾长度、直径、单个去梗质量、枝梗质量占比、脆碎度,并分析辛夷内在成分指标与外观性状指标的相关性;同时采用熵权法对内在成分指标进行综合评分,分析综合评分与外观性状的相关性。结果挥发油含量与花蕾长度、单个去梗质量、直径呈非常显著正相关(P<0.01),木兰脂素含量与外观指标无显著相关性(P>0.05),综合评分与花蕾长度、单个去梗质量、直径呈非常显著正相关(P<0.01)。结论该研究证实了传统等级依据花蕾长度划分理念的科学性,同时发现挥发油含量及内在成分综合评分指标与单个去梗质量、直径呈非常显著正相关,即个大、饱满、质重者优,丰富了辛夷规格等级的划分依据。Objective To analyze the correlation between the appearance characteristics and the intrinsic quality of Magnoliae flos,and to provide the classification basis for the specifications of Magnoliae flos,the entropy-weight method and quality discrimination by character was used in this study.Methods The essential oil content,magnoliin content,bud length,bud diameter,single bud weight without stem,stem occupancy and fragility of 21 batches of Magnoliae flos were determined,and the correlation between intrinsic component indexes and appearance characteristics was analyzed.Entropy-weight method was used to score the intrinsic component indexes,and the correlation between comprehensive scores and appearance characteristics was analyzed.Results The results showed that there was a significant positive correlation between the essential oil content and the bud length,the bud diameter,the single bud weight without stem(P<0.01).There was no significant correlation between magnoliin content and appearance indexes(P>0.05).There were significant positive correlations between the comprehensive score and the bud length,the bud diameter,or the single bud weight without stem(P<0.01).Conclusion This study confirmed the scientific nature of the traditional classification based on bud length,and found that the intrinsic component index was significantly positively correlated with the bud diameter and single bud weight without stem.That is,the bigger,fuller and heavierones were superior,which enriched the classification basis of the specifications of Magnoliae flos.

关 键 词：辛夷 辨状论质 熵权法 相关性 外观性状 内在质量 等级划分 

分 类 号：R284.1[医药卫生—中药学]