艾迪注射液联合其他疗法治疗消化系统肿瘤的研究进展  

The Progress of Aidi Injection Combined with Other Therapies on the Treatment of Gastrointestinal Cancer

作　　者：郭盛 余小祥[2] 张维权 李小兰 韩瑶瑶[3,4] 张秋萍 陈信[3,4] 郭宏伟 GUO Sheng;YU Xiaoxiang;ZHANG Weiquan;LI Xiaolan;HAN Yaoyao;ZHANG Qiuping;CHENXin;GUO Hongwei(The First Affiliated Hospital of Guangxi Medical University,Nanning 530021 Guangxi,China;923 Hospital of the Joint Service Support Force of the People's Liberation Army,Nanning 530021 Guangxi,China;College of Pharmacy,Guangxi Medical University,Nanning 530021 Guangxi,China;Key Laboratory of Longevity and Aging-Related Diseases of Chinese Ministry of Education&Center for Translational Medicine,Guangxi Medical University,Nanning 530021 Guangxi,China)

机构地区：[1]广西医科大学第一附属医院,广西南宁530021 [2]中国人民解放军联勤保障部队第923医院,广西南宁530021 [3]广西医科大学药学院,广西南宁530021 [4]长寿与老年相关疾病教育部重点实验室&广西医科大学转化医学研究中心,广西南宁530021

出　　处：《中药新药与临床药理》2021年第8期1224-1230,共7页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：国家自然科学基金资助项目(82074347);广西自然科学基金联合资助培育项目(2018GXNSFAA294080);广西药学一流学科建设项目(GXFCDP-PS-2018)。

摘　　要：消化系统肿瘤是严重威胁人类生命健康的一类疾病。大量研究发现艾迪注射液联合化疗、放疗等其他疗法治疗消化系统肿瘤效果明显,可有效地改善患者的生存质量,降低不良反应的发生率,提高临床安全性和延长生存期。艾迪注射液抗肿瘤机制可能与其抑制肿瘤细胞增殖和侵袭、促进凋亡、调节自噬、增强免疫功能、逆转耐药性以及抑制肿瘤血管新生有关。该文从治疗方案、临床优势及治疗机制3个方面综述了艾迪注射液联合其他疗法治疗消化系统肿瘤的研究进展,可为艾迪注射液联合其他疗法治疗消化系统肿瘤提供新思路。Gastrointestinal cancer is a serious disease endangering human life and health.A large number of studies have found that Aidi injection combined with chemotherapy,radiotherapy and other therapies are effective in the treatment of gastrointestinal cancer and effectively improve the quality of life of patients,reduce the incidence of adverse reactions,improve clinical safety and prolong survival period.The anti-tumor mechanism of Aidi injection may involve inhibiting tumor cell proliferation and invasion,promoting apoptosis,regulating autophagy,enhancing immune function,reversing drug resistance and suppressing tumor angiogenesis.This article reviews the advances of Aidi injection combined with other therapies on the treatment of gastrointestinal cancer from three aspects,including treatment plan,clinical advantages and treatment mechanism.The review can provide new ideas for Aidi injection combined with other therapies on the treatment of gastrointestinal cancer.

关 键 词：艾迪注射液 消化系统肿瘤 化疗 治疗方案 治疗机制 

分 类 号：R285.6[医药卫生—中药学]