探讨血清肿瘤标记物糖类抗原125、鳞状细胞癌相关抗原、人多效蛋白联合检测在肺癌诊疗中的价值  

The value of combined detection of serum tumor markers CA125,Scc-Ag and PTN in diagnosing and treating lung cancer

作　　者：张念伦 吴鹏[2] 徐风亮[2] Zhang Nianlun

机构地区：[1]山东省日照市结核病防治所,山东日照276800 [2]山东省日照市人民医院,山东日照276826

出　　处：《中医临床研究》2021年第14期18-21,共4页Clinical Journal Of Chinese Medicine

摘　　要：目的:探讨血清肿瘤分子标记物糖类抗原125(Carbohydrate Aantigen 125,CA125)、鳞状细胞癌相关抗原(Squamous Cell Carcinoma Associated Antigen,Scc-Ag)、人多效蛋白(Pleiotrophin,PTN)联合动态检测在肺癌的诊断和监控治疗中的价值。方法:应用电化学发光法及酶联免疫吸附测定(Enzyme-linked Immunosorbent Assay,ELISA)法检测124例肺癌患者、50例肺部良性病变患者及50例健康体检者血清CA125、Scc-Ag、PTN水平,回顾性统计分析其与肺癌不同临床病理因素的相关性,以单因素分析之Kaplan-Meier法(生存分析)评估预后。结果:肺癌患者血清CA125、Scc-Ag、PTN表达水平明显高于肺部良性病变组及正常对照组(P<0.01),良性病变组和正常对照组差异无统计学意义(P>0.05)。肺癌患者血清CA125、Scc-Ag、PTN水平与患者的性别、年龄、肿瘤发生部位无明显相关性(P>0.05),与肿瘤大小、组织学类型、临床分期明显相关(均P<0.05)。肺癌血清CA125、Scc-Ag、PTN高水平表达组预后无事件(无复发、转移或死亡)生存率明显低于低水平表达组(P<0.01)。CA125、Scc-Ag、PTN三项联合检测诊断肺癌敏感性、准确性、阴性预测值与各单项及部分组合检测比较明显提高(P<0.05)。结论:CA125、Scc-Ag、PTN与肺癌生物学行为密切相关,三项联合动态检测可以作为肺癌早期诊断和监控治疗的有效指标。Objective:To explore the value of combined dynamic detection of serum tumor markers CA125,Scc-Ag,and PTN in the diagnosis,monitoring and treatment of lung cancer.Methods:Electrochemiluminescence and ELISA were used to detect serum CA125,Scc-Ag,and PTN levels in 124 patients with lung cancer,50 patients with benign lung disease and 50 healthy subjects.The correlation between the detection indicators and different clinicopathological factors of lung cancer was retrospectively analyzed.The Kaplan-Meier method was used to evaluate the prognosis.Results:The expression levels of serum CA125,Scc-Ag and PTN in patients with lung cancer were significantly higher than those in the benign disease group and the normal group(P<0.01),and there was no statistical difference between the benign disease group and the normal group(P>0.05).Serum CA125,Scc-Ag,PTN levels were not significantly correlated with gender,age,and tumor site of lung cancer patients(P>0.05),but were significantly correlated with tumor size,histological type,clinical stage(all P<0.05).The no prognostic event(no recurrence,metastasis or death)survival of patients with high-level expressiong of serum CA125,Scc-Ag,and PTN was significantly lower than patients with low-level expression of the above indicators(P<0.01).There were statistically significant differences in sensitivity,accuracy,and negative predictive value of the three combined detection of CA125,Scc-Ag,and PTN in the diagnosis of lung cancer were significantly improved compared with single item and parts of the combined detection(P<0.05),respectively.Conclusion:CA125,Scc-Ag,and PTN are closely related to the biological behavior of lung cancer patients,and the three combined dynamic detection can be applied as effective indicators for early diagnosis,monitoring and treatment of lung cancer.

关 键 词：肺癌 肿瘤标记物 生物学 联合检测 诊疗 

分 类 号：R392.6[医药卫生—免疫学]