迷迭香酚酸类成分研究  

Phenolic acids of Rosmarinus officinalis

作　　者：何默忠 曹伟 曾光尧 陈正收 周应军 HE Mo-zhong;CAO Wei;ZENG Guang-yao;CHEN Zheng-shou;ZHOU Ying-jun(Hunan Yifang Tianjiang Pharmaceutical Co.,Ltd.,Changde 415000,China;Xiangya Shool of Pharmaceutical Sciences,Central South University,Changsha 410006,China;Hunan Jinhan Pharmaceutical Co.,Ltd.,Liuyang 410300,China)

机构地区：[1]湖南一方天江药业有限责任公司,湖南常德415000 [2]中南大学湘雅药学院,湖南长沙410006 [3]湖南今汉药业有限公司,湖南浏阳410300

出　　处：《中草药》2021年第13期3798-3803,共6页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81573314)。

摘　　要：目的研究迷迭香Rosmarinus officinalis中的酚酸类化学成分。方法迷迭香叶用80%乙醇提取,碱溶酸沉处理后,经硅胶柱色谱、聚酰胺柱色谱、亲脂性Sephadex LH-20柱色谱、重结晶等手段进行分离纯化,并结合多种波谱方法进行结构鉴定。结果从迷迭香叶80%乙醇提取物中分离得9个酚酸类成分,包括一系列松香烷二萜类化合物,分别为7β-乙氧基迷迭香醌(1)、7-乙酰氧基香茶菜酚A(2)、鼠尾草酚(3)、迷迭香酚(4)、表迷迭香酚(5)、异迷迭香酚(6)、20-去氧鼠尾草酚(7)、木香醌酸(8)、桦木酸(9)。结论化合物1和2为新化合物。Objective To study the phenolic acids of Rosmarinus officinalis.Methods The compounds were isolated and purified from the 80%ethanol extract of leaves of R.officinalis after a process of alkali-solution and acid-isolation by several methods including silica gel column chromatography,polyamide column chromatography,lipophilic Sephadex LH-20 column chromatography,recrystal,et al.And their structures were elucidated on the basis of spectral data.Results Nine phenolic acids were isolated and identified as 7β-ethoxy rosmaqunione(1),7-acetoxy atuntzensin A(2),carnosol(3),rosmanol(4),epirosmanol(5),isorosmanol(6),20-deoxocarnosol(7),royleanonic acid(8)and betulinic acid(9).Conclusion Compound 1 and 2 are new compounds.

关 键 词：迷迭香 酚酸类 松香烷二萜 7β-乙氧基迷迭香醌 7-乙酰氧基香茶菜酚A 鼠尾草酚 迷迭香酚 

分 类 号：R284.1[医药卫生—中药学]