铁死亡的作用机制及其在肿瘤耐药中的研究进展  

Research Progress of Iron Death and Its Role in Tumor Drug Resistance

作　　者：王莉[1] 黄杰安[2] 梁俐[1] 覃蒙斌[2] WANG Li;HUANG Jie-An;LIANG Li;QIN Meng-Bin(Department of Oncology,Second Affiliated Hospital of Guangxi Medical University,Nanning 530007,China;Department of Gastroenterology,Second Affiliated Hospital of Guangxi Medical University,Nanning 530007,China)

机构地区：[1]广西医科大学第二附属医院肿瘤内科,南宁530007 [2]广西医科大学第二附属医院消化内科,南宁530007

出　　处：《中国药物经济学》2021年第6期125-128,共4页China Journal of Pharmaceutical Economics

基　　金：广西高校中青年教师科研基础能力提升项目(2020KY03017);广西自然科学基金项目(2018GXNSFBA050072);广西医科大学第二附属医院国基培育项目(GJPY2019003)。

摘　　要：铁死亡是最近被定义的一种铁依赖性的,由脂质过氧化物累积所触发的,不同于坏死、凋亡、自噬的细胞调节性死亡(regulated cell death,RCD)方式。铁死亡与肿瘤密切相关,有望成为治疗肿瘤的一个新的突破点。同时,肿瘤细胞可通过抑制铁死亡,增强活性氧(reactive oxygen species,ROS)失衡介导的氧化应激防御能力,诱导肿瘤细胞耐药。本研究对铁死亡的发生机制以及铁死亡在肿瘤耐药中发挥的作用进行综述,为克服肿瘤耐药提供新的思路。Ferroptosis is a recently defined iron-dependent,triggered by the accumulation of lipid peroxides,which is different from the regulated cell death(RCD)mode of necrosis,apoptosis,and autophagy.Ferroptosis is closely related to tumors and is expected to become a new breakthrough point in the treatment of tumors.At the same time,tumor cells can inhibit iron death,enhance the oxidative stress defense ability mediated by reactive oxygen species(ROS)imbalance,and induce tumor cell resistance.This study reviewed the mechanism of ferroptosis and the role of ferroptosis in tumor resistance,and provided new ideas for overcoming tumor resistance.

关 键 词：铁死亡 肿瘤耐药 铁代谢 活性氧 谷胱甘肽 

分 类 号：R979.1[医药卫生—药品]