抗登革病毒化合物及作用机制研究进展  

Research progress on anti-dengue virus compounds and mechanism of action

作　　者：汪芳 罗荣华[2] 姚债文 郑永唐[2,3] WANG Fang;LUO Rong-hua;YAO Zhai-wen;ZHENG Yong-tang(College of Medicine,Kunming University of Science and Technology,Kunming,Yunnan 650500;Key Laboratory of Bioactive Peptides of Yunnan Province/Key Laboratory of Animal Models and Human Disease Mechanisms of the Chines Academy of Sciences,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,Yunnan 650223;College of Pharmaceutical Sciences,Soochow University,Suzhou,Jiangsu 215021,China)

机构地区：[1]昆明理工大学医学院,云南昆明650500 [2]中国科学院昆明动物研究所,云南省活性多肽研究与利用重点实验室/中国科学院动物模型与人类疾病机理重点实验室,云南昆明650223 [3]苏州大学药学院,江苏苏州215021

出　　处：《热带医学杂志》2021年第6期807-811,共5页Journal of Tropical Medicine

基　　金：云南省重大科技专项计划课题(2017ZF007)。

摘　　要：登革病毒感染引起登革热,是一种蚊媒传播病毒,给人类的生命健康造成了严重的威胁。目前尚无有效的抗登革病毒药物和疫苗用于临床治疗和预防。因此,研究对病毒生命周期中起关键作用的蛋白及宿主受体,设计出抗登革病毒靶标的抑制剂,从而选择性地抑制病毒的感染复制具有重要意义。本文就目前在研的抗登革病毒化合物及作用机制进行综述。Dengue virus infection causes dengue fever,which is a mosquito-borne virion that poses a serious threat to human life and health. Currently,there are no effective anti-dengue virus drugs and vaccines for clinical treatment. Therefore,it is of great significance to study the proteins and host receptors that play a key role in the life cycle of the virus,and to design inhibitors against dengue virus targets,so as to selectively inhibit the infection and replication of the virus. This article reviews the current anti-dengue virus compounds and their mechanisms of action.

关 键 词：登革病毒 登革热 抗登革药物 登革出血热 登革休克综合征 

分 类 号：R512.8[医药卫生—内科学]