心脉隆注射液治疗慢性心力衰竭病人的疗效及近期预后的临床研究  

Clinical study on the efficacy and short-term prognosis of Xinmailong injection in the treatment of chronic heart failure

作　　者：王亚旭 孙林[1] 姜雪梅[1] 官兵[1] 林志[1] 王永洁 孙文静[1] 何永福 WANG Ya-xu;SUN Lin;JIANG Xue-mei;GUAN Bing;LIN Zhi;WANG Yong-jie;SUN Wen-jing;HE Yong-fu(Department of Cardiology,The Second Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650000,China)

机构地区：[1]昆明医科大学第二附属医院心内科,云南昆明650000

出　　处：《蚌埠医学院学报》2021年第7期862-865,共4页Journal of Bengbu Medical College

基　　金：云南省科技厅-昆明医科大学应用基础研究联合专项资金项目2018FE001(-053)。

摘　　要：目的:探究心脉隆注射液对于慢性心力衰竭病人的治疗效果及近期预后的临床价值。方法:选择心内科收治的慢性心力衰竭病人86例,采用随机数字表法分为研究组(43例)和对照组(43例)。对照组采用血管紧张素转酶抑制剂ACEI、血管紧张素Ⅱ受体拮抗剂、利尿剂、强心剂、β受体阻断剂进行治疗。研究组在对照组病人用药基础上,给予心脉隆注射液进行治疗。比较2组病人的6 min步行距离、氨基末端脑钠肽前体T-proBNP数值、左心室射血分数及MLHFQ评分、MACE发生率五项指标情况。结果:2组治疗2个疗程后,研究组病人6 min步行距离、左心室射血分数差均明显高于对照组(P<0.01);N氨基末端脑钠肽前体数值明显低于对照组(P<0.01)。研究组的治疗有效率高于对照组(P<0.05);MLHFQ评分低于对照组(P<0.05);出院2个月后心血管不良事件发生率小于对照组(P<0.01)。结论:心脉隆注射液治疗慢性心力衰竭病人的疗效及近期预后效果较好,可为临床治疗提供依据。Objective:To explore the efficacy and short-term prognosis of Xinmailong injection in the treatment of chronic heart failure.Methods:Eighty-six patients with chronic heart failure were randomly divided into the study group(43 cases)and control group(43 cases).The control group was treated with the ACE inhibitor,angiotensinⅡreceptor antagonist,diuretic,cardiotonic agent,andβ-receptor blocker.On the basis of the medication of the control group,the study group was additionally treated with Xinmailong injection.The 6-miniute walking distance,NT-probNP level,left ventricular ejection fraction(LVEF/%),MLHFQ score and MACE incidence were compared between two groups.Results:After two courses of treatment,the 6-minute walking distance and LVEF/%in study group were significantly higher those in control group(P<0.01).The NT-proBNP level in study group was significantly lower than that in control group(P<0.01).The treatment efficiency in study group was higher than that in control group(P<0.05),and the MLHFQ score in study group was lowher than that in control group(P<0.05).The incidence of major adverse cardiovascolar events in study group after 2 months of discharge was less than that in control group(P<0.01).Conclusions:Xinmailong injection in the treatment of chronic heart failure has good curative effect and short-term prognosis of patients,which can provide a basis for clinical treatment.

关 键 词：慢性心力衰竭 心脉隆注射液 6 min步行距离 氨基末端脑钠肽前体 左心室射血分数 

分 类 号：R541.6[医药卫生—心血管疾病]