非小细胞肺癌病人PD-L1表达与临床及影像学特征关系  

Relationship between PD-L1 expression and clinical and imaging features in patients with non-small cell lung cancer

作　　者：方园 谢军 章俊强 徐从景 FANG Yuan;XIE Jun;ZHANG Jun-qiang;XU Cong-jing(School of Medicine,Anhui University of Science and Technology,Huainan Anhui 232001;Lung Cancer Diagnosis and Treatment Center of Huainan Oriental Group Cancer Hospital,Huainan Anhui 232001;Department of Respiratory,Anhui Provincial Hospital,The First Affiliated Hospital of Chinese University of Science and Technology,Hefei Anhui 230001,China)

机构地区：[1]安徽理工大学医学院,安徽淮南232001 [2]淮南东方集团肿瘤医院肺癌诊治中心,安徽淮南232001 [3]中国科学技术大学第一附属医院,安徽省立医院呼吸内科,安徽合肥230001

出　　处：《蚌埠医学院学报》2021年第7期878-883,共6页Journal of Bengbu Medical College

基　　金：安徽省淮南市科技计划项目(3064)。

摘　　要：目的:探讨非小细胞肺癌(non small-cell lung cancer,NSCLC)组织中程序性死亡配体-1(programmed cell death ligand-1,PD-L1)的表达与病人临床特征及影像学特征的关系。方法:回顾性分析进行PD-L1检测的NSCLC病人187例的临床特征及胸部影像学特征。根据病人PD-L1表达情况,将病人分为高表达组40例、低表达组65例和阴性组82例,其中高表达组和低表达组作为阳性组。比较各组病人PD-L1表达与临床特征及影像学特征的关系。结果:3组病人性别、年龄、吸烟史及病理类型差异均无统计学意义(P>0.05),TNM分期差异有统计学意义(P<0.01)。高表达组病人胸部CT表现中分叶、气管支气管侵犯、毛刺征、胸腔积液比例均较低表达组中多见(P<0.05~P<0.01)。阳性组肺纤维化、病灶贴近胸膜、胸膜牵拉征、胸膜增厚、多发结节、毛刺征比例差异均有统计学意义(P<0.05~P<0.01)。结论:不同PD-L1表达的NSCLC病人TNM分期和影像学特征中胸膜牵拉征、胸膜增厚、毛刺征、多发结节、纤维化、贴近胸膜表现均存在差异。Objective:To explore the relationship between the programmed cell death ligand-1(PD-L1)expression in the tissues of non-small cell lung cancer(NSCLC)and clinical and chest imaging features.Methods:The clinical features and chest imaging features of 187 NSCLC patients who received PD-L1 detection were retrospectively analyzed.According to the expression of PD-L1,the patients were divided into the high expression group(40 cases),low expression group(65 cases)and negative group(82 cases),and the high expression group and low expression group were regarded as the positive group.The relationship between PD-L1 expression and clinical and imaging features were analyzed and compared among three groups.Results:There was no statistical significance in gender,age,smoking history and pathological type among three groups(P>0.05),but there was statistical significance in TNM staging(P<0.01).The chest CT findings showed that the who patients with lobulation,tracheobronchial invasion,burr sign and pleural effusion in high expression group were more than those in low expression group(P<0.05 to P<0.01).The differences of the pulmonary fibrosis,lesions close to the pleura,pleural pull sign,pleural thickening,multiple nodules and burr sign in the positive group were statistically significant(P<0.05 to P<0.01).Conclusions:The TNM staging and imaging features of NSCLC patients with different PD-L1 expressions show the differences in pleural traction sign,pleural thickening,burr sign,multiple nodules,fibrosis,and pleural proximal manifestations.

关 键 词：非小细胞肺癌 程序性死亡配体-1 计算机断层扫描 

分 类 号：R734.2[医药卫生—肿瘤]