CHD病人HbA1c、2hPG水平与冠状动脉病变程度的相关性分析  

Correlation analysis of the levels of HbA1c and 2 hPG with degree of coronary artery disease in CHD patients

作　　者：徐晓飞[1] 朱章进 牛杰[1] 黎敬锋 XU Xiao-fei;ZHU Zhang-jin;NIU Jie;LI Jing-feng(Department of Cardiology,The First People′s Hospital of Chuzhou,Chuzhou Anhui 239000,China)

机构地区：[1]安徽省滁州市第一人民医院心内科四病区,239000

出　　处：《蚌埠医学院学报》2021年第7期917-920,共4页Journal of Bengbu Medical College

摘　　要：目的:分析冠状动脉粥样硬化性心脏病(CHD)病人血清中糖化血红蛋白(HbA1c)、2 h血糖(2hPG)水平与其冠状动脉病变程度的相关性。方法:收集接受治疗的CHD病人80例为观察组,根据冠脉病变评分(Gensini评分)将观察组病人分为轻度病变组(26例)、中度病变组(38例)和重度病变组(16例)。收集同一时期冠状动脉造影(CAG)检查结果正常的受试者80例为对照组。比较2组病人各项代谢指标水平;比较冠脉不同病变程度CHD病人HbA1c、2hPG水平;分析CHD病人HbA1c与2hPG水平之间的相关性;分析CHD病人冠脉病变程度与HbA1c、2hPG的相关性。结果:观察组病人血清中HbA1c、2hPG水平均明显高于对照组(P<0.01);随着CHD病人冠脉病变程度加重,血清中HbA1c、2hPG水平呈现逐渐上升趋势(P<0.01)。CHD病人血清中HbA1c水平与2hPG水平呈明显正相关关系(r=0.332,P<0.01);CHD病人冠脉病变程度与其血清中HbA1c水平、2hPG水平均呈正相关关系(rs=0.546,P<0.01;rs=0.437,P<0.01)。结论:CHD病人血清中HbA1c、2hPG水平明显升高,且与其冠脉病变程度呈正相关关系。Objective:To analyze the correlation between the levels of glycosylated hemoglobin(HbA1c),2-hour postprandial blood glucose(2hPG)and degree of coronary artery disease in patients with coronary atherosclerotic heart disease(CHD).Methods:A total of 80 patients with CHD were set as the observation group,and divided into the mild disease group(26 cases),moderate disease group(38 cases)and severe disease group(16 cases)according to the Gensini score.During the same period,80 patients with normal coronary angiography(CAG)were set as the control group.The metabolic indexes between the observation group and control group were compared,and the levels of HbA1c and 2hPG among the CHD patients with different degrees of coronary lesions were compared.The correlation between HbA1c and 2hPG in patients with CHD was analyzed.The correlation between the levels of HbA1c and 2hPG,and between the levels of HbA1c,2hPG and severity of CHD disease were analyzed.Results:The serum levels of HbA1c and 2hPG in observation group were significantly higher than those in control group(P<0.01).The levels of HbA1c and 2hPG gradually increased with the aggravation of severity of coronary artery lesions in CHD patients(P<0.01).There was a significant positive correlation between HbA1c level and 2hPG level in CHD patients(r=0.332,P<0.01).There was a significant positive correlation between the degree of coronary lesions and levels of HbA1c,2hPG in CHD patients(rs=0.546,P<0.01;rs=0.437,P<0.01).Conclusions:The levels of HbA1c and 2hPG in patients with CHD significantly increase,which is significantly positively correlated with degree of coronary lesions.

关 键 词：冠状动脉粥样硬化性心脏病 糖化血红蛋白 血糖 

分 类 号：R543.3[医药卫生—心血管疾病]