薛氏4号方治疗湿热侵络型原发性高血压临床观察  

Clinical observation on Xueshi No.4 Decoction in on primary hypertension with damp-heat intruding collaterals

作　　者：孙侃[1] SUN Kan(Shijiazhuang Hospital of Traditional Chinese Medicine,Shijiazhuang 050051,Hebei,China)

机构地区：[1]石家庄市中医院,河北石家庄050051

出　　处：《现代中西医结合杂志》2021年第23期2545-2549,共5页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：河北省中医药管理局科研计划项目(2020340)。

摘　　要：目的观察薛氏4号方联合苯磺酸氨氯地平片治疗湿热侵络型原发性高血压的临床疗效与安全性。方法将2019年9月—2020年3月石家庄市中医院诊治的120例湿热侵络型原发性高血压患者按照随机数表法分为2组,对照组60例给予苯磺酸氨氯地平片治疗,观察组60例在对照组治疗基础上给予薛氏4号方治疗,2组均治疗4周。比较2组临床疗效、中医症状评分、血压[收缩压(SBP)和舒张压(DBP)]、血压变异性[晨起血压峰值、7 d最高血压值、24 h收缩压标准差(24hSBPSD)、白昼收缩压标准差(dSBPSD)、夜间收缩压标准差(nSBPSD)、24 h舒张压标准差(24hDBPSD)、白昼舒张压标准差(dDBPSD)、夜间舒张压标准差(nDBPSD)]、生活质量及不良反应发生情况。结果观察组总有效率为93.3%(56/60),对照组为78.3%(47/60),观察组明显高于对照组(P<0.05);2组治疗后中医症状评分、血压、晨起收缩压峰值、7 d最高收缩压值、24 hSBPSD、 dSBPSD、 nSBPSD均明显降低(P均<0.05),生活质量评分均明显增高(P均<0.05),且治疗后观察组上述各指标改善情况均明显优于对照组(P均<0.05)。观察组和对照组不良反应发生率分别为6.7%(4/60)和3.3%(2/60),2组比较差异无统计学意义(P>0.05)。结论薛氏4号方联合苯磺酸氨氯地平片治疗湿热侵络型原发性高血压患者疗效更好,可有效改善患者中医症状,降低患者短时和长时血压变异性,进而提高患者生活质量。Objective It is to observe the clinical efficacy and safety of Xueshi No.4 Decoction combined with amlodipine besylate tablets in the treatment of essential hypertension with damp-heat intruding collaterals.Methods A total of 120 patients with essential hypertension with damp-heat intruding collaterals diagnosed and treated in Shijiazhuang Hospital of Traditional Chinese Medicine from September 2019 to March 2020 were divided into 2 groups according to the random number table method.60 patients in the control group were treated with amlodipine besylate tablets,60 cases in the observation group were treated with Xueshi No.4 Decoction on the basis of the treatment in the control group,and both groups were treated for 4 weeks.The clinical efficacy,TCM symptom score,blood pressure[systolic blood pressure(SBP)and diastolic blood pressure(DBP)],blood pressure variability[morning peak blood pressure,7-day maximum blood pressure value,24 h systolic blood pressure standard deviation(24hSBPSD),day systolic blood pressure standard deviation(dSBPSD),night systolic blood pressure standard deviation(nSBPSD),24 h diastolic blood pressure standard deviation(24hDBPSD),day diastolic blood pressure standard deviation(dDBPSD),night diastolic blood pressure standard deviation(nDBPSD)],quality of life and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 93.3%(56/60),and that in the control group was 78.3%(47/60),the observation group was significantly higher than the control group(P<0.05);after treatment,the TCM symptom score,blood pressure,morning peak systolic blood pressure,7-day maximum blood pressure value,24hSBPSD,dSBPSD,and nSBPSD were significantly reduced(all P<0.05),and the scores of quality of life were significantly increased(all P<0.05),and the improvement of the above indicators in the observation group after treatment was significantly better than that in the control group(P<0.05).The incidence of adverse reactions in the observation g

关 键 词：苯磺酸氨氯地平片 薛氏4号方 原发性高血压 血压变异性 不良反应 

分 类 号：R544.1[医药卫生—心血管疾病]