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作 者:张冠峰[1] ZHANG Guanfeng(Medical Department,Tai′an Maternal and Child Health Hospital in Shandong Province,Tai′an271000,China)
机构地区:[1]山东省泰安市妇幼保健院医务科,山东泰安271000
出 处:《中国现代医生》2021年第20期73-76,共4页China Modern Doctor
摘 要:目的探讨对喘息性支气管炎患儿应用黄龙止咳颗粒+布地奈德的治疗效果及其作用机制。方法选择2019年1月至2020年7月我院96例喘息性支气管炎患儿为研究对象,依据随机数字表法分为对照组及研究组,每组各48例。对照组实施布地奈德雾化吸入治疗,研究组实施布地奈德雾化吸入治疗+黄龙止咳颗粒口服治疗,比较两组治疗有效率、临床症状消失时间、治疗前后患儿血清炎症因子水平变化及治疗期间不良反应发生率。结果研究组治疗有效率为95.83%,高于对照组的83.33%,差异有统计学意义(P<0.05);研究组患儿临床症状消失时间均短于对照组,差异均有统计学意义(P<0.05);治疗前两组患儿CRP、TNF-α、IL-6、IL-10水平比较,差异无统计学意义(P>0.05);治疗后研究组患儿CRP、TNF-α、IL-6、IL-10水平均低于对照组,差异有统计学意义(P<0.05);研究组不良反应总发生率为4.17%,与对照组的2.08%比较,差异无统计学意义(P>0.05)。结论对喘息性支气管炎患儿治疗中,应用黄龙止咳颗粒+布地奈德治疗,可提升临床疗效、缩短康复时间、改善患儿炎症因子水平,且治疗安全性理想,具有推广价值。Objective To explore the therapeutic effect of Huanglong Cough Granules combined with budesonide on children with asthmatic bronchitis,and to explore the mechanism of drug treatment.Methods A total of 96 children with asthmatic bronchitis admitted to our hospital between January 2019 and July 2020 were selected as the study subjects.According to the random number table method,the subjects were divided into the control group and the study group,with 48 children in each group.Patients in the control group were given budesonide aerosol inhalation treatment,while patients in the study group were given budesonide aerosol inhalation treatment combined with taking Huanglong Cough Granules orally.The effective rates,disappearance time of clinical symptoms,changes of serum inflammatory factors before and after treatment,and incidences of adverse reactions during treatment were compared between the two groups.Results The effective rate of the study group was 95.83%,which was higher than that of 83.33%in the control group,and the difference was statistically significant(P<0.05).The disappearance time of clinical symptoms in the study group was shorter than that in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference of CRP,TNF-α,IL-6 and IL-10 levels between the two groups(P>0.05).After treatment,the levels of CRP,TNF-α,IL-6 and IL-10 in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The total incidence of adverse reactions in the study group was 4.17%,which was similar to that of 2.08%in the control group,and the difference was not statistically significant(P>0.05).Conclusion In the treatment of children with asthmatic bronchitis,the application of Huanglong Cough Granules combined with budesonide can enhance the clinical efficacy,shorten the rehabilitation time,and lower the level of inflammatory factors in children.This treatment is safe and worth promotion.
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