氯硝柳胺通过RANKL信号通路对骨质疏松症的作用  

Effects of niclosamide on osteoporosis through RANKL signal pathway

作　　者：李慧敏[1] 焦玉睿 胡希鉴 郭剑津[2] 叶琳 赵倩[2] 朱亦堃[2] LI Hui-min;JIAO Yu-rui;HU Xi-jian;GUO Jian-jin;YE Lin;ZHAO Qian;ZHU Yi-kun(Department of Endocrinology, The Second Clinical Medical College of Shanxi Medical University,Taiyuan 030001, China;Department of Endocrinology, The Second Hospital of Shanxi Medical University,Taiyuan 030001, China)

机构地区：[1]山西医科大学第二临床医学院内分泌科,太原030001 [2]山西医科大学第二医院内分泌科,太原030001

出　　处：《中华骨质疏松和骨矿盐疾病杂志》2021年第3期308-312,共5页Chinese Journal Of Osteoporosis And Bone Mineral Research

摘　　要：骨质疏松症(osteoporosis,OP)是以骨量降低,骨组织微结构损坏,骨强度下降而导致骨脆性增加的全身代谢性疾病。目前骨质疏松症的治疗用药相对于其复杂的发病机制还有一定的局限性,研发治疗效果明显且长期应用不良反应小的药物是目前该领域的热点。氯硝柳胺具有干扰细胞线粒体氧化磷酸化的作用,近年来发现其在糖代谢、抗肿瘤、骨代谢等领域均有潜在的应用价值,未来有望通过开发药物的多效性应用于不同疾病的治疗。本文对近年来关于氯硝柳胺通过调控OPG/RANKL/RANK信号通路影响骨代谢的相关文献进行综述,为进一步研究该药在骨质疏松症治疗中的作用提供思路。Osteoporosis(OP)is a systemic metabolic disease with low bone mass,damage of bone microstructure,and bone strength,which leads to the increase of bone brittleness.At present,the use of drugs for the treatment of osteoporosis has some limitations compared with the complex pathogenesis.The research and development of drugs with obvious therapeutic effects and less side effects is a hot spot in this field.Niclosamide can interfere with oxidative phosphorylation of cellular mitochondria.In recent years,it has been found that niclosamide has potential application value in the fields of glucose metabolism,anti-tumor,bone metabolism,and so on.Niclosamide is expected to be used in the treatment of different diseases through the development of drug multipotency.We summarize the recent literature of the effects of niclosamide on bone metabolism by regulating OPG/RANKL/RANK signal pathway to provide ideas for niclosamide in the treatment of osteoporosis.

关 键 词：骨质疏松症 氯硝柳胺 骨代谢 

分 类 号：R681[医药卫生—骨科学]