黄腐酸钾作为分散剂用于10%阿维菌素悬浮剂的开发  

Formulation of abamectin 100 SC by fulvic acid potassium as dispersant

作　　者：李浩林 张大侠 于建 张鹏 李北兴 慕卫 刘峰 LI Haolin;ZHANG Daxia;YU Jian;ZHANG Peng;LI Beixing;MU Wei;LIU Feng(Key Laboratory of Pesticide Toxicology and Application Technology,College of Plant Protection,Shandong Agricultural University,Taian 271018,Shandong Province,China;Key Laboratory of Ecological Control of Crop Pests in Fujian and Taiwan,College of Plant Protection,Fujian Agriculture and Forestry University,Fuzhou 350002,China;Shandong Agriculture and Fertilizer Science and Technology Co.,LTD.,Taian,271699,Shandong Province,China;Jinan Tianbang Chemical Co.LTD.,Jinan 251600,China)

机构地区：[1]山东农业大学植物保护学院农药毒理与应用技术重点实验室,山东泰安271018 [2]福建农林大学植物保护学院闽台作物有害生物生态防控国家重点实验室,福州350002 [3]山东农大肥业科技有限公司,山东泰安271699 [4]济南天邦化工有限公司,济南251600

出　　处：《农药学学报》2021年第4期803-811,共9页Chinese Journal of Pesticide Science

基　　金：国家自然科学基金(31972293;32001953);山东省重点研发计划(2019GNC106099)。

摘　　要：黄腐酸钾源于腐植酸,目前广泛用作叶面肥和功能水溶肥,基于其天然属性和结构特点,本研究以阿维菌素为模式农药,评价了黄腐酸钾作为分散剂用于制备农药悬浮剂的可行性。通过湿法研磨制备得到以黄腐酸钾为分散剂的10%阿维菌素悬浮剂,以研磨效率及制剂在冷、热、常温贮存条件下的稳定性为指标,对配方中的分散剂、润湿剂及增稠剂等助剂进行了筛选。结果表明:配方中分散剂黄腐酸钾质量分数为3%,润湿剂OP-10为1%,增稠剂黄原胶为0.15%、硅酸镁铝为0.5%,pH调节剂柠檬酸为0.02%,消泡剂X60为0.1%时,所制备悬浮剂各项指标较优,其中,细度(75μm)≥99%,冷、热贮稳定性均合格。室内生物活性测定结果表明,在阿维菌素质量分数为0.1~2.5 mg/L时,该制剂对南方根结线虫Meloidogyne incognita的活性与常规阿维菌素悬浮剂相当。因此,黄腐酸钾可作为分散剂用于制备性能良好的阿维菌素悬浮剂。Fulvic acid,derived from humic acid,is widely used in foliar fertilizers and functional watersoluble fertilizers at present.Based on its natural properties and structural characteristics,this study used avermectin as a model pesticide to evaluate the feasibility of potassium fulvic acid as a dispersant in the preparation of pesticide suspension concentrate(SC).Wet grinding was adopted during the preparation of abamectin 100 SC with fulvicacidpotassium as dispersant.The grinding efficiency and the stability,under the condition of cold,hot or normal temperature storage,of the preparation were considered as the main indexes to screen the dispersant,wetting agent,thickening agent and other auxiliary agents.The results indicated that in the optimal formula of SC,the mass fraction of fulvic acid potassium addition as dispersant was 3%,the mass fraction of OP-10 as wetting agent was 1%,thickening agent xanthan gum and magnesium aluminosilicate were 0.15%and 0.5%,respectively,the mass fraction of citric acid as pH regulatorcitric acidaddition was 0.02%,and the mass fraction of X60 as defoamer was 0.1%.Among them,fineness(75μm)≥99%,cold and heat storage stability were qualified.The results from biological activity shown that,when the dosage of abamectin was 0.1 mg/L to 2.5 mg/L,the toxicity of the preparation against southern root-knot nematode Meloidogyne incognita was at the same level with the commercial abamectin SC.In conclusion,fulvic acid potassium can be used as dispersant to prepare abamectin SC with good properties.

关 键 词：黄腐酸钾 分散剂 阿维菌素 悬浮剂 贮存稳定性 南方根结线虫 

分 类 号：TQ450.45[化学工程—农药化工] TQ450.6